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General information


634
20308562
Homo sapiens (9606)
GO:0043616 keratinocyte proliferation

Study information


Bioprocess study
HaCaT cell

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-210 Antagomir transfection miRNA downregulation E2F3

Detailed information about selected miRNA


hsa-mir-210
Down-regulation of basal miR-210 levels in keratinocytes significantly increased cell proliferation. Consistently, delivery of miR-210 mimic clearly compromised keratinocyte proliferation.
Antagomir transfection
miRNA downregulation
   

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment
E2F3 down

Comments


General comment: HIF-1 alpha drives miR-210 expression, which in turn compromises cell proliferation by targeting E2F3.