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General information


624
20552018
Mus musculus (10090)
disease
Alzheimer disease

Study information


Patient study phenotype-control
In vivo analysis of the Abeta plaque-forming APP23 mouse model; APP23 mice are expressing human APP751 cDNA containing a double mutation (K651M and N652L); brains from mice at different ages (from 2-13 months) were harvested; non-transgenic littermates were used as controls;
brain

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 mmu-let-7i quantitative PCR miRNA downregulation 1.34
2 mmu-let-7i quantitative PCR miRNA downregulation 1.35
3 mmu-mir-148b quantitative PCR miRNA overexpression 1.35
4 mmu-mir-148b quantitative PCR miRNA downregulation 1.32
5 mmu-mir-181c quantitative PCR miRNA downregulation 1.53
6 mmu-mir-21 quantitative PCR miRNA downregulation 1.23
7 mmu-mir-21 quantitative PCR miRNA downregulation 1.42
8 mmu-miR-30c (mmu-mir-30c-1, mmu-mir-30c-2) quantitative PCR miRNA downregulation 1.14
9 mmu-miR-30c (mmu-mir-30c-1, mmu-mir-30c-2) quantitative PCR miRNA downregulation 1.38
10 mmu-mir-361 quantitative PCR miRNA downregulation 1.38
11 mmu-miR-409-3p (mmu-mir-409) quantitative PCR miRNA downregulation 1.5
12 mmu-miR-409-3p (mmu-mir-409) quantitative PCR miRNA downregulation 1.66
13 mmu-miR-409-3p (mmu-mir-409) quantitative PCR miRNA downregulation 1.23
14 mmu-miR-9 (mmu-mir-9-1, mmu-mir-9-2, mmu-mir-9-3) quantitative PCR miRNA downregulation 1.87
15 mmu-miR-9 (mmu-mir-9-1, mmu-mir-9-2, mmu-mir-9-3) quantitative PCR miRNA downregulation 1.46

Detailed information about selected miRNA


mmu-let-7i
from two month-old mice
quantitative PCR
miRNA downregulation
1.34    

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment

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