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General information

Mus musculus (10090)
Alzheimer disease
In neurodegenerative disorders such as Alzheimer's disease, brain miRNA profiles are altered; thus miRNA dysfunction could be both a cause and a consequence of disease.

Study information

Cell culture study
from 16.5-day old embryonic C57BL/6 mice
hippocampal cell line
Primary hippocampal neurons

miRNA list

Nr miRNA Method Further methods Evidence Foldchange Genes
1 mmu-let-7i quantitative PCR miRNA downregulation 1.33
2 mmu-mir-137 quantitative PCR miRNA downregulation 1.27
3 mmu-mir-181c quantitative PCR miRNA downregulation 2.86
4 mmu-mir-20b quantitative PCR miRNA downregulation 3.57
5 mmu-miR-30c (mmu-mir-30c-1, mmu-mir-30c-2) quantitative PCR miRNA downregulation 1.35
6 mmu-mir-376b quantitative PCR miRNA overexpression 2.61
7 mmu-miR-409-3p (mmu-mir-409) quantitative PCR miRNA downregulation 3.85
8 mmu-mir-700 quantitative PCR miRNA downregulation 1.82
9 mmu-miR-9 (mmu-mir-9-1, mmu-mir-9-2, mmu-mir-9-3) quantitative PCR miRNA downregulation 1.32

Detailed information about selected miRNA

quantitative PCR
miRNA downregulation

Genes associated with selected miRNA

target gene regulation mechanism of regulation comment


General comment: Significantly deregulated microRNAs in primary hippocampal cells with amyloid beta peptid (42) treatment.