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General information


487
19043531
Homo sapiens (9606)
disease
Squamous cell carcinoma, head and neck

Study information


Patient study phenotype-control
8
5
The authors analyzed HNSCC (head and neck squamous cell carcinoma) lymph node tissue samples from a set of 5 benign and eight histologically positive nodes.
lymph node

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-205 quantitative PCR miRNA overexpression

Detailed information about selected miRNA


hsa-mir-205
The expression of mir-205 in the HNSCC-positive lymph node samples was several hundred-fold higher than the other metastatic lesions when normalized to the benign lymph node samples.
quantitative PCR
miRNA overexpression
   

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment

Comments


General comment: The authors showed that mir-205 is not expressed in normal lymph node tissue. The difference in the relative expression of mir-205 between benign and metastatic lymph node samples demonstrates the potential of this marker to detect metastatic squamous cell carcinoma in lymph node specimens as well its ability of to distinguish among metastases from different primary tumor types.