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The expression of mir-205 in the HNSCC-positive lymph node samples was several hundred-fold higher than the other metastatic lesions when normalized to the benign lymph node samples.
Genes associated with selected miRNA
mechanism of regulation
The authors showed that mir-205 is not expressed in normal lymph node tissue.
The difference in the relative expression of mir-205 between benign and metastatic lymph node samples demonstrates the potential of this marker to detect metastatic squamous cell carcinoma in lymph node specimens as well its ability of to distinguish among metastases from different primary tumor types.