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General information

Homo sapiens (9606)
Squamous cell carcinoma, head and neck

Study information

Patient study phenotype-control
The authors analyzed HNSCC (head and neck squamous cell carcinoma) lymph node tissue samples from a set of 5 benign and eight histologically positive nodes.
lymph node

miRNA list

Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-205 quantitative PCR miRNA overexpression

Detailed information about selected miRNA

The expression of mir-205 in the HNSCC-positive lymph node samples was several hundred-fold higher than the other metastatic lesions when normalized to the benign lymph node samples.
quantitative PCR
miRNA overexpression

Genes associated with selected miRNA

target gene regulation mechanism of regulation comment


General comment: The authors showed that mir-205 is not expressed in normal lymph node tissue. The difference in the relative expression of mir-205 between benign and metastatic lymph node samples demonstrates the potential of this marker to detect metastatic squamous cell carcinoma in lymph node specimens as well its ability of to distinguish among metastases from different primary tumor types.