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General information


435
18728182
Homo sapiens (9606)
disease
Immunological
Monoclonal gammopathy of undetermined significance (MGUS)

Study information


Patient study phenotype-control
5
4
CD138+ PCs (plasma cells) from MGUS patients and PCs from four healthy patients were analysed;
plasma cell

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-let-7c miRNA microarray miRNA overexpression 3.31
2 hsa-let-7f-1 miRNA microarray miRNA overexpression 10
3 hsa-let-7g miRNA microarray miRNA overexpression 2.92
4 hsa-mir-1-1 miRNA microarray miRNA overexpression 12.4
5 hsa-mir-103-1 miRNA microarray miRNA overexpression 7.78
6 hsa-mir-106a miRNA microarray miRNA overexpression 5.84
7 hsa-mir-106b miRNA microarray quantitative PCR miRNA overexpression 10.5
8 hsa-mir-107 miRNA microarray miRNA overexpression 7.12
9 hsa-mir-124-1 miRNA microarray miRNA downregulation 2.564
10 hsa-mir-126 miRNA microarray miRNA overexpression 14.62
11 hsa-mir-130b miRNA microarray miRNA overexpression 9.49
12 hsa-mir-133b miRNA microarray miRNA overexpression 7.38
13 hsa-mir-142 miRNA microarray miRNA overexpression 14.5
14 hsa-mir-148a miRNA microarray miRNA overexpression 4.22
15 hsa-mir-15a miRNA microarray miRNA overexpression 5.3
16 hsa-mir-16-1 miRNA microarray miRNA overexpression 12.98
17 hsa-mir-17 miRNA microarray miRNA overexpression 13.37
18 hsa-mir-181a-1 miRNA microarray quantitative PCR miRNA overexpression 13.98
19 hsa-mir-181c miRNA microarray miRNA overexpression 10.7
20 hsa-mir-187 miRNA microarray miRNA downregulation 2.5
21 hsa-mir-195 miRNA microarray miRNA overexpression 11.02
22 hsa-mir-200c miRNA microarray miRNA overexpression 12.16
23 hsa-mir-21 miRNA microarray miRNA overexpression 15.62
24 hsa-mir-210 miRNA microarray miRNA overexpression 4.18
25 hsa-mir-222 miRNA microarray miRNA overexpression 3.78
26 hsa-mir-23a miRNA microarray miRNA overexpression 10.1
27 hsa-mir-25 miRNA microarray quantitative PCR miRNA overexpression 7.04
28 hsa-mir-26a-1 miRNA microarray miRNA overexpression 14.1
29 hsa-mir-26b miRNA microarray miRNA overexpression 16.02
30 hsa-mir-27a miRNA microarray miRNA overexpression 4.11
31 hsa-mir-29a miRNA microarray miRNA overexpression 7.22
32 hsa-mir-29b-1 miRNA microarray miRNA overexpression 8.61
33 hsa-mir-29c miRNA microarray miRNA overexpression 6.71
34 hsa-mir-30a miRNA microarray miRNA overexpression 18.1
35 hsa-mir-30b miRNA microarray miRNA overexpression 16.18
36 hsa-mir-30c-1 miRNA microarray miRNA overexpression 11.4
37 hsa-mir-30d miRNA microarray miRNA overexpression 3.6
38 hsa-mir-326 miRNA microarray miRNA downregulation 5.263
39 hsa-mir-328 miRNA microarray miRNA downregulation 6.667
40 hsa-mir-330 miRNA microarray miRNA overexpression 13.7
41 hsa-mir-339 miRNA microarray miRNA downregulation 10
42 hsa-mir-34c miRNA microarray miRNA downregulation 14.286
43 hsa-mir-376c miRNA microarray miRNA overexpression 6.9
44 hsa-mir-9-1 miRNA microarray miRNA overexpression 7.27
45 hsa-mir-93 miRNA microarray quantitative PCR miRNA overexpression 13.42
46 hsa-mir-95 miRNA microarray miRNA overexpression 25.91
47 hsa-mir-96 miRNA microarray miRNA downregulation 3.333

Detailed information about selected miRNA


hsa-let-7c
miRNA microarray
miRNA overexpression
3.31    

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment

Comments


General comment: Multiple myeloma (MM), a B-cell neoplasm can occur de novo or develop from a benign condition called monoclonal gammopathy of undetermined significance (MGUS) at a rate of about 1% per year. To study specific alterations associated with early pathogenetic events of MM, the authors profiled CD138+ PCs (Plasma cells) from MGUS patients and healthy PCs.