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General information


413
18307259
Homo sapiens (9606)
disease
Hepatocellular carcinoma
Hepatocellular carcinoma, associated with hepatitis B/C viral infection and cirrhosis

Study information


Patient study phenotype-control
10
3
HCV-positive hepatocellular carcinoma liver tissues versus normal liver parenchyma. The liver tumors consisted of 11 HCCs (n = 2 grade 1, n = 5 grade 2, n = 4 grade 3) as well as 8 DNs (n = 3 low-grade, n = 5 high-grade). In nearly all patients cirrhosis was assigned.
liver

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-let-7g quantitative PCR miRNA overexpression 2.39
2 hsa-mir-100 quantitative PCR miRNA overexpression 2.14
3 hsa-mir-106a quantitative PCR miRNA downregulation 14.286
4 hsa-mir-10a quantitative PCR miRNA overexpression 2.14
5 hsa-mir-125b-1 quantitative PCR miRNA overexpression 2.2
6 hsa-mir-134 quantitative PCR miRNA downregulation 4.348
7 hsa-mir-137 quantitative PCR miRNA downregulation 6.25
8 hsa-mir-145 quantitative PCR miRNA downregulation 16.667
9 hsa-mir-147 quantitative PCR miRNA downregulation 5.263
10 hsa-mir-15a quantitative PCR miRNA overexpression 2.15
11 hsa-mir-16-1 quantitative PCR miRNA overexpression 1.82
12 hsa-mir-185 quantitative PCR miRNA downregulation 2.941
13 hsa-mir-198 quantitative PCR miRNA downregulation 16.667
14 hsa-mir-199b quantitative PCR miRNA downregulation 14.286
15 hsa-mir-204 quantitative PCR miRNA downregulation 11.111
16 hsa-mir-21 quantitative PCR miRNA downregulation 7.692
17 hsa-mir-218-1 quantitative PCR miRNA downregulation 9.091
18 hsa-mir-299 quantitative PCR miRNA overexpression 2.14
19 hsa-mir-29c quantitative PCR miRNA downregulation 8.333
20 hsa-mir-302b quantitative PCR miRNA downregulation 25
21 hsa-mir-326 quantitative PCR miRNA overexpression 1.69
22 hsa-mir-330 quantitative PCR miRNA downregulation 14.286
23 hsa-mir-370 quantitative PCR miRNA overexpression 3.04
24 hsa-mir-376c quantitative PCR miRNA downregulation 25
25 hsa-mir-9-1 quantitative PCR miRNA overexpression 2.53
26 hsa-mir-95 quantitative PCR miRNA downregulation 11.111

Detailed information about selected miRNA


hsa-let-7g
quantitative PCR
miRNA overexpression
2.39    

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment

Comments


General comment: In addition to the shown miRNAs the authors described the following downregulated miRNAs: miR-159a (fold change 0.06), which could not be found, and miR-9* (fold change 0.17) and miR-302b* (fold change 0.05). By analyzing selected miRNA expression patterns across the spectrum from normal to cirrhotic, further to dysplastic and finally to malignant liver parenchyma, the authors were able to show that many of the aberrations of miRNA expression levels in HCCs were already present in peritumorous cirrhotic tissue, albeit to a lesser degree.