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Hepatocellular carcinoma, associated with hepatitis B/C viral infection and cirrhosis
Patient study phenotype-control
HCV-positive hepatocellular carcinoma liver tissues versus normal liver parenchyma. The liver tumors consisted of 11 HCCs (n = 2 grade 1, n = 5 grade 2, n = 4 grade 3) as well as 8 DNs (n = 3 low-grade, n = 5 high-grade). In nearly all patients cirrhosis was assigned.
In addition to the shown miRNAs the authors described the following downregulated miRNAs: miR-159a (fold change 0.06), which could not be found, and miR-9* (fold change 0.17) and miR-302b* (fold change 0.05).
By analyzing selected miRNA expression patterns across the spectrum from normal to cirrhotic, further to dysplastic and finally to malignant liver parenchyma, the authors were able to show that many of the aberrations of miRNA expression levels in HCCs were already present in peritumorous cirrhotic tissue, albeit to a lesser degree.