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General information


394
18223217
Homo sapiens (9606)
disease
Hepatocellular carcinoma
Hepatocellular carcinoma, associated with hepatitis B/C viral infection and cirrhosis

Study information


Patient study phenotype-phenotype
Phenotype 1: HCC (hepatocellular carcinoma) V(-) C(-) patients (n=17); Phenotype 2: HCC V(+) C(+) patients (n=12); C = cirrhosis; V = viral hepatitis infection;
liver

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-let-7b quantitative PCR miRNA overexpression 2
2 hsa-let-7d quantitative PCR miRNA overexpression 2.1
3 hsa-let-7f-1 quantitative PCR miRNA overexpression 2.1
4 hsa-let-7f-2 quantitative PCR miRNA overexpression 6.8
5 hsa-let-7i quantitative PCR miRNA overexpression 2.1
6 hsa-mir-103-1 quantitative PCR miRNA overexpression 2.2
7 hsa-mir-103-2 quantitative PCR miRNA overexpression 2.2
8 hsa-mir-124-1 quantitative PCR miRNA overexpression 2.9
9 hsa-mir-124-2 quantitative PCR miRNA overexpression 2.9
10 hsa-mir-124-3 quantitative PCR miRNA overexpression 2.9
11 hsa-mir-125b-1 quantitative PCR miRNA overexpression 3.7
12 hsa-mir-134 quantitative PCR miRNA overexpression 2.1
13 hsa-mir-135b quantitative PCR miRNA overexpression 2.8
14 hsa-mir-139 quantitative PCR miRNA overexpression 2.3
15 hsa-mir-141 quantitative PCR miRNA overexpression 2.3
16 hsa-mir-143 quantitative PCR miRNA overexpression 2
17 hsa-mir-147 quantitative PCR miRNA overexpression 2.4
18 hsa-mir-149 quantitative PCR miRNA overexpression 2.3
19 hsa-mir-151 quantitative PCR miRNA overexpression 2.3
20 hsa-mir-16-2 quantitative PCR miRNA overexpression 2
21 hsa-mir-181b-1 quantitative PCR miRNA overexpression 2.6
22 hsa-mir-181b-2 quantitative PCR miRNA overexpression 2.6
23 hsa-mir-192 quantitative PCR miRNA overexpression 2.3
24 hsa-mir-193a quantitative PCR miRNA overexpression 2.5
25 hsa-mir-194-1 quantitative PCR miRNA overexpression 3.1
26 hsa-mir-194-2 quantitative PCR miRNA overexpression 3.1
27 hsa-mir-195 quantitative PCR miRNA overexpression 2.2
28 hsa-mir-196b quantitative PCR miRNA overexpression 2.1
29 hsa-mir-198 quantitative PCR miRNA overexpression 2.9
30 hsa-mir-200b quantitative PCR miRNA overexpression 3.5
31 hsa-mir-200c quantitative PCR miRNA overexpression 2.7
32 hsa-mir-204 quantitative PCR miRNA overexpression 2.2
33 hsa-mir-208a quantitative PCR miRNA overexpression 2.3
34 hsa-mir-212 quantitative PCR miRNA overexpression 2.2
35 hsa-mir-214 quantitative PCR miRNA overexpression 2.4
36 hsa-mir-216a quantitative PCR miRNA overexpression 2.1
37 hsa-mir-22 quantitative PCR miRNA overexpression 2.1
38 hsa-mir-221 quantitative PCR miRNA overexpression 3.2
39 hsa-mir-222 quantitative PCR miRNA overexpression 2.4
40 hsa-mir-223 quantitative PCR miRNA overexpression 2.3
41 hsa-mir-224 quantitative PCR miRNA overexpression 2.7
42 hsa-mir-23a quantitative PCR miRNA overexpression 2.3
43 hsa-mir-23b quantitative PCR miRNA overexpression 2.3
44 hsa-mir-25 quantitative PCR miRNA overexpression 2.3
45 hsa-mir-299 quantitative PCR miRNA overexpression 2
46 hsa-mir-302b quantitative PCR miRNA overexpression 2.5
47 hsa-mir-30b quantitative PCR miRNA overexpression 2.1
48 hsa-mir-328 quantitative PCR miRNA overexpression 2.5
49 hsa-mir-330 quantitative PCR miRNA overexpression 2.5
50 hsa-mir-331 quantitative PCR miRNA overexpression 2.9
51 hsa-mir-337 quantitative PCR miRNA overexpression 2.6
52 hsa-mir-338 quantitative PCR miRNA overexpression 3
53 hsa-mir-370 quantitative PCR miRNA overexpression 2.5
54 hsa-mir-371 quantitative PCR miRNA overexpression 2.4
55 hsa-mir-9-2 quantitative PCR miRNA overexpression 2.2

Detailed information about selected miRNA


hsa-let-7b
quantitative PCR
miRNA overexpression
2    

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment

Comments


General comment: The authors show that a large number of miRNAs have increased expression in the hepatitis-positive and cirrhotic specimens compared with the liver tissues that developed HCC in the context of a histologically normal liver or in normal liver not associated with HCCs.