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General information


333
18383392
Homo sapiens (9606)
disease
Rheumatoid arthritis

Study information


Patient study phenotype-control
The authors analysed RASFs (rheumatoid arthritis synovial fibroblasts) stimulated with proinflammatory mediators (TNF-alpha, IL-1-beta and TLR ligands).
synovial fibroblast

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-146a quantitative PCR miRNA overexpression 2.9 - 5.6
2 hsa-mir-155 quantitative PCR miRNA microarray miRNA overexpression 1.9 - 5.7 MMP1MMP3

Detailed information about selected miRNA


hsa-mir-146a
quantitative PCR
miRNA overexpression
2.9   -   5.6

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment

Comments


General comment: Additional experiments of expression of mir-155 in CD14+ cells in samples of synovial fluid and peripheral blood cells from patients with rheumatoid arthritis (RA) were done. They showed that CD14+ cells in the RA synovial fluid expressed 4.4-fold higher levels of mir-155 compared to CD14+ cells in peripheral blood.