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General information


322
18555017
Homo sapiens (9606)
disease
Hepatocellular carcinoma

Study information


Cell culture study
The authors analysed 18 cell lines, 11 HCC cell lines, derived from chronic carriers of HBV (HKCI-3, -4, -7, -8, -9, Hep3B, PLC/PRF/5, SNU387, SNU398, SNU423 and SNU475), 4 HCC cell lines, derived from HCV-infected papients (HKCI-C1, -C2, -C3 and HuH-7), and 3 cell lines were non-B non-C related (HKCI-2, -10, and HepG2).
SNU-423 cell

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-122 miRNA microarray miRNA downregulation
2 hsa-mir-126 miRNA microarray miRNA downregulation
3 hsa-mir-182 miRNA microarray miRNA overexpression
4 hsa-mir-221 miRNA microarray miRNA overexpression
5 hsa-mir-222 miRNA microarray quantitative PCR, Northern Blot miRNA overexpression 11.35
6 hsa-mir-223 miRNA microarray quantitative PCR, Northern Blot miRNA downregulation 100 STMN1
7 hsa-mir-31 miRNA microarray miRNA overexpression

Detailed information about selected miRNA


hsa-mir-122
miRNA microarray
miRNA downregulation
   

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment

Comments


General comment: In addition the authors analysed the downregulation of mir-321, which is described in miRBase as a fragment of a Arg-tRNA. Statistical analysis suggested deregulations of 4 miRNAs (mir-15a, mir-210, mir-7 and mir-324-3p) to be more profound in HBV-related cell lines, whereas 5 miRNAs (mir-99b, mir-18, mir-342, mir-145 and mir-214) being differently regulated in the HCV-related cell lines.