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General information


218
17222355
Homo sapiens (9606)
GO:0001666 : response to hypoxia

Study information


Bioprocess study
SCC (primary human oral squamous cell carcinoma) cell lines were grown both in a normoxic atmosphere and in an environment that mimics the hypoxia encountered in solid head and neck tumors.
cell culture
The following primary human oral squamous cell carcinoma (SCC) cell lines were analyzed: SCC-4, SCC-9, UMB-10B.

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-let-7e miRNA microarray miRNA overexpression 2.26
2 hsa-let-7g miRNA microarray miRNA overexpression 2.22
3 hsa-let-7i miRNA microarray miRNA overexpression 2.12
4 hsa-mir-101-1 miRNA microarray miRNA downregulation 3.73
5 hsa-mir-122 miRNA microarray miRNA downregulation 13.54
6 hsa-mir-141 miRNA microarray miRNA downregulation 3.05
7 hsa-mir-148a miRNA microarray miRNA overexpression 2.3
8 hsa-mir-148b miRNA microarray miRNA downregulation 3.48
9 hsa-mir-15a miRNA microarray miRNA overexpression 2.28
10 hsa-mir-186 miRNA microarray miRNA downregulation 3.63
11 hsa-mir-191 miRNA microarray miRNA overexpression 4.19
12 hsa-mir-195 miRNA microarray miRNA downregulation 6.36
13 hsa-mir-197 miRNA microarray miRNA downregulation 2
14 hsa-mir-19a miRNA microarray miRNA overexpression 2.46
15 hsa-mir-19a miRNA microarray miRNA downregulation 3.95
16 hsa-mir-200a miRNA microarray miRNA overexpression 2.2
17 hsa-mir-210 miRNA microarray miRNA overexpression 4.16
18 hsa-mir-214 miRNA microarray miRNA overexpression 5.39
19 hsa-mir-22 miRNA microarray miRNA downregulation 2.1
20 hsa-mir-29b-1 miRNA microarray miRNA downregulation 3.66
21 hsa-mir-30b miRNA microarray miRNA overexpression 2.19
22 hsa-mir-30e miRNA microarray miRNA downregulation 5.93
23 hsa-mir-31 miRNA microarray miRNA overexpression 3.97
24 hsa-mir-331 miRNA microarray miRNA downregulation 2.02
25 hsa-mir-373 miRNA microarray miRNA overexpression 2.85
26 hsa-mir-374a miRNA microarray miRNA downregulation 4.17
27 hsa-mir-378 miRNA microarray miRNA downregulation 2.01
28 hsa-mir-424 miRNA microarray miRNA downregulation 3.68
29 hsa-mir-498 miRNA microarray miRNA overexpression 2.94
30 hsa-mir-563 miRNA microarray miRNA overexpression 5.17
31 hsa-mir-572 miRNA microarray miRNA overexpression 6.16
32 hsa-mir-628 miRNA microarray miRNA overexpression 4.5
33 hsa-mir-637 miRNA microarray miRNA overexpression 4.96
34 hsa-mir-7-1 miRNA microarray miRNA overexpression 2.2
35 hsa-mir-98 miRNA microarray Northern Blot miRNA overexpression 4.56 HMGA2

Detailed information about selected miRNA


hsa-let-7e
miRNA microarray
miRNA overexpression
2.26    

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment

Comments


General comment: The miRNA-profile shows the different expression following hypoxia in SCC cells.