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General information


211
18464261
Homo sapiens (9606)
disease
Squamous cell carcinoma, head and neck
Squamous cell carcinoma (SCC) of the tongue

Study information


Patient study phenotype-control
13
13
tongue

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-133b miRNA microarray quantitative PCR miRNA downregulation 5.3 PKM2
2 hsa-mir-133a-1 miRNA microarray quantitative PCR miRNA downregulation 12.5 PKM2

Detailed information about selected miRNA


hsa-mir-133a-1
Authors' designation: hsa-miR-133a with location on chromosome 18;
miRNA microarray
quantitative PCR
miRNA downregulation
12.5    

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment
PKM2 down

Comments


General comment: Immunohistochemical staining results of tongue SCC tissues suggested that PKM2 was overexpressed in tongue SCC and was associated with the downregulation of miR-133a and miR-133b.