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General information


205
18381414
Homo sapiens (9606)
disease
Squamous cell carcinoma, head and neck
Oral squamous carcinoma (OSCC)

Study information


Cell culture study
HSC-3 cell
18 OSCC (oral squamous cell carcinoma) cell lines were analysed, the immortalized oral keratinocyte line RT7 used as a control.

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-96 quantitative PCR miRNA downregulation
2 hsa-mir-95 quantitative PCR miRNA downregulation
3 hsa-mir-9-3 quantitative PCR miRNA overexpression
4 hsa-mir-9-2 quantitative PCR miRNA overexpression
5 hsa-mir-9-1 quantitative PCR miRNA overexpression
6 hsa-mir-376c quantitative PCR miRNA downregulation
7 hsa-mir-374a quantitative PCR miRNA overexpression
8 hsa-mir-373 quantitative PCR miRNA downregulation
9 hsa-mir-372 quantitative PCR miRNA downregulation
10 hsa-mir-371 quantitative PCR miRNA downregulation
11 hsa-mir-370 quantitative PCR miRNA downregulation
12 hsa-mir-367 quantitative PCR miRNA downregulation
13 hsa-mir-34c quantitative PCR miRNA downregulation
14 hsa-mir-34b quantitative PCR miRNA downregulation
15 hsa-mir-34a quantitative PCR miRNA downregulation
16 hsa-mir-342 quantitative PCR miRNA downregulation
17 hsa-mir-340 quantitative PCR miRNA overexpression
18 hsa-mir-338 quantitative PCR miRNA downregulation
19 hsa-mir-337 quantitative PCR miRNA downregulation
20 hsa-mir-331 quantitative PCR miRNA downregulation
21 hsa-mir-330 quantitative PCR miRNA downregulation
22 hsa-mir-31 quantitative PCR miRNA overexpression
23 hsa-mir-30e quantitative PCR miRNA downregulation
24 hsa-mir-30d quantitative PCR miRNA downregulation
25 hsa-mir-302c quantitative PCR miRNA downregulation
26 hsa-mir-302b quantitative PCR miRNA downregulation
27 hsa-mir-302a quantitative PCR miRNA downregulation
28 hsa-mir-299 quantitative PCR miRNA downregulation
29 hsa-mir-296 quantitative PCR miRNA downregulation
30 hsa-mir-27b quantitative PCR miRNA downregulation
31 hsa-mir-27a quantitative PCR miRNA downregulation
32 hsa-mir-26b quantitative PCR miRNA downregulation
33 hsa-mir-23b quantitative PCR miRNA downregulation
34 hsa-mir-23a quantitative PCR miRNA downregulation
35 hsa-mir-224 quantitative PCR miRNA overexpression
36 hsa-mir-223 quantitative PCR miRNA downregulation
37 hsa-mir-215 quantitative PCR miRNA downregulation
38 hsa-mir-204 quantitative PCR miRNA downregulation
39 hsa-mir-203 quantitative PCR miRNA downregulation
40 hsa-mir-200c quantitative PCR miRNA downregulation
41 hsa-mir-200b quantitative PCR miRNA downregulation
42 hsa-mir-199b quantitative PCR miRNA downregulation
43 hsa-mir-199a-2 quantitative PCR miRNA downregulation
44 hsa-mir-199a-1 quantitative PCR miRNA downregulation
45 hsa-mir-197 quantitative PCR miRNA downregulation
46 hsa-mir-193a quantitative PCR miRNA downregulation E2F6
47 hsa-mir-184 quantitative PCR miRNA downregulation
48 hsa-mir-181a-1 quantitative PCR miRNA overexpression
49 hsa-mir-155 quantitative PCR miRNA downregulation
50 hsa-mir-148a quantitative PCR miRNA downregulation
51 hsa-mir-146a quantitative PCR miRNA overexpression
52 hsa-mir-140 quantitative PCR miRNA overexpression
53 hsa-mir-139 quantitative PCR miRNA downregulation
54 hsa-mir-138-2 quantitative PCR miRNA downregulation
55 hsa-mir-138-1 quantitative PCR miRNA downregulation
56 hsa-mir-137 quantitative PCR miRNA downregulation CDK6
57 hsa-mir-133b quantitative PCR miRNA downregulation
58 hsa-mir-132 quantitative PCR miRNA downregulation
59 hsa-mir-128-1 quantitative PCR miRNA downregulation
60 hsa-mir-126 quantitative PCR miRNA overexpression
61 hsa-mir-125a quantitative PCR miRNA downregulation
62 hsa-mir-122 quantitative PCR miRNA downregulation
63 hsa-mir-10a quantitative PCR miRNA overexpression
64 hsa-mir-107 quantitative PCR miRNA downregulation
65 hsa-let-7g quantitative PCR miRNA downregulation
66 hsa-let-7e quantitative PCR miRNA downregulation
67 hsa-let-7d quantitative PCR miRNA downregulation
68 hsa-let-7a-3 quantitative PCR miRNA downregulation
69 hsa-let-7a-2 quantitative PCR miRNA downregulation
70 hsa-let-7a-1 quantitative PCR miRNA downregulation

Detailed information about selected miRNA


hsa-let-7a-1
quantitative PCR
miRNA downregulation
   

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment

Comments


General comment: Compared with expression levels in RT7, frequent up-regulation (>1.5-fold expression) was found only in 11 of 148 (7.4%) miRNAs, whereas frequent down-regulation (<0.5-fold expression) was observed in 54 of 148 (36.5%) miRNAs, suggesting that some subsets of miRNAs are generally down-regulated in OSCC lines compared with normal oral keratinocytes.