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In addition, the following NSCLC (non-small cell lung cancer) cell lines were analyzed: A459, A549, H460. Goal of this paper was to differentiate the MicroRNA signature between TRAIL-(TNF-related apoptosis-inducing ligand) resistant and TRAIL-sensitive cells. Calu-1 = TRAIL-resistant, A459, A549 = semi-resistant, H460 = sensitive to TRAIL.
The inhibition of miR-221 and -222 expression with the specific anti-miR
inhibitor in CALU-1 TRAIL-resistant cells was able to change the insensitive TRAIL phenotype to a sensitive one.
Forced overexpression of the miR-222, -100 and -221, but not of miR-125b, in the sensitive H460 cells increased resistance to TRAIL in these cells.