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General information


177
15766527
Homo sapiens (9606)
disease
Lung cancer

Study information


Patient study phenotype-control
12
12
Lung cancer patients with squamous cell carcinomas (stage IB or IIA).
lung

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-let-7a-1 miRNA microarray miRNA downregulation KRASNRAS
2 hsa-let-7c miRNA microarray Northern Blot miRNA downregulation KRASNRAS

Detailed information about selected miRNA


hsa-let-7a-1
Authors' designation: hsa-miR-7a;
miRNA microarray
miRNA downregulation
   

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment
KRAS down
NRAS down

Comments


General comment: The results showed that the expression of let-7 inversely correlates with expression of RAS protein in lung cancer tissues. The fact that RAS is significantly overexpressed in lung tumor samples strongly implicates let-7 as a tumor suppressor in lung tissue and suggests a possible mechanism.