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General information


176
18932017
Homo sapiens (9606)
disease
Breast cancer

Study information


Patient study phenotype-control
344
Fresh tumor samples were collected during surgery from 344 patients diagnosed with primary breast cancer.
breast

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-21 quantitative PCR miRNA overexpression TGFB1

Detailed information about selected miRNA


hsa-mir-21
The expression of miR-21 in tumor samples was measured with a TaqMan microRNA assay using U6 as reference.
quantitative PCR
miRNA overexpression
   

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment
TGFB1 up TGF-b is able to increase the expression of miR-21 through the SMAD signal transduction pathway which stimulates the transition of primary miR-21 (pri-miR-21) to precursor miR-21 (premiR-21).

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