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General information


150
16266980
Homo sapiens (9606)
disease
Lung cancer

Study information


Cell culture study
In addition, 13 NSCLC (non-small cell lung cancer) cell lines, 5 SCLC (small cell lung cancer) cell lines, 2 normal cell lines and normal lung were analysed.
Calu-6 cell

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-17 Northern Blot polycistron overexpression
2 hsa-mir-18a Northern Blot polycistron overexpression
3 hsa-mir-19a Northern Blot polycistron overexpression
4 hsa-mir-20a Northern Blot polycistron overexpression

Detailed information about selected miRNA


hsa-mir-17
Authors' designation: hsa-miR-17-3p;
Northern Blot
polycistron overexpression
   

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment

Comments


General comment: The miR-17-92 cluster, which comprises seven miRNAs and resides in intron 3 of the C13orf25 gene at 13q31.3, is markedly overexpressed in lung cancers, especially with small-cell lung cancer histology. The authors conclude that the miR-17-92 cluster has significant stimulatory activity in lung cancer cell growth and a major role of the C13orf25 gene may probably be as a vehicle for the expression of this polycistronic miRNAs in this cluster.