General search

List as:
Entries miRNAs
Search type:
Fuzzy Strict


Specific search

List as:
Entries miRNAs
Search type:
Fuzzy Strict

About phenomir

List all entries
List all diseases
List all miRNAs


© 2009 - Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH) Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany

Data Protection Statement

MIPS Databases and associated information are protected by copyright. This server and its associated data and services are for academic, non-commercial use only. The Helmholtz Zentrum München has no liability for the use of results, data or information which have been provided through this server. Neither the use for commercial purposes, nor the redistribution of MIPS database files to third parties nor the distribution of parts of files or derivative products to any third parties is permitted.

Home > List > Detailed view

General information

Homo sapiens (9606)
Lung cancer

Study information

Cell culture study
In addition, 13 NSCLC (non-small cell lung cancer) cell lines, 5 SCLC (small cell lung cancer) cell lines, 2 normal cell lines and normal lung were analysed.
Calu-6 cell

miRNA list

Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-17 Northern Blot polycistron overexpression
2 hsa-mir-18a Northern Blot polycistron overexpression
3 hsa-mir-19a Northern Blot polycistron overexpression
4 hsa-mir-20a Northern Blot polycistron overexpression

Detailed information about selected miRNA

Authors' designation: hsa-miR-17-3p;
Northern Blot
polycistron overexpression

Genes associated with selected miRNA

target gene regulation mechanism of regulation comment


General comment: The miR-17-92 cluster, which comprises seven miRNAs and resides in intron 3 of the C13orf25 gene at 13q31.3, is markedly overexpressed in lung cancers, especially with small-cell lung cancer histology. The authors conclude that the miR-17-92 cluster has significant stimulatory activity in lung cancer cell growth and a major role of the C13orf25 gene may probably be as a vehicle for the expression of this polycistronic miRNAs in this cluster.