General search


List as:
Entries miRNAs
Search type:
Fuzzy Strict


help

Specific search


List as:
Entries miRNAs
Search type:
Fuzzy Strict

help
About phenomir
Download

List all entries
List all diseases
List all miRNAs

Home

© 2009 - Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH) Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany


Imprint


Disclaimer:
MIPS Databases and associated information are protected by copyright. This server and its associated data and services are for academic, non-commercial use only. The Helmholtz Zentrum München has no liability for the use of results, data or information which have been provided through this server. Neither the use for commercial purposes, nor the redistribution of MIPS database files to third parties nor the distribution of parts of files or derivative products to any third parties is permitted.

Home > List > Detailed view

General information


102
18270258
Homo sapiens (9606)
disease
Thyroid carcinoma, follicular
Follicular thyroid carcinoma, oncocytic
Most thyroid carcinomas originate from thyroid follicular cells and are subdivided into well-differentiated papillary carcinoma (PC) and follicular carcinoma (FC) (the latter further subclassified into conventional and oncocytic type). Both PCs and FCs may progress to poorly differentiated carcinoma (PDC) or may completely lose differentiation to give rise to anaplastic carcinoma (AC). Follicular adenomas (FAs) are benign thyroid tumors and can be of either conventional type or oncocytic type. Less than 5% of cells within the thyroid gland are C-cells that give rise to medullary carcinoma (MC).

Study information


Patient study phenotype-control
5
The number of patients was not explicitly mentioned.
thyroid gland

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-181a-1 quantitative PCR miRNA overexpression 14.3
2 hsa-mir-181b-1 quantitative PCR miRNA overexpression 19.7
3 hsa-mir-182 quantitative PCR miRNA overexpression 15.6
4 hsa-mir-183 quantitative PCR miRNA overexpression 26.6
5 hsa-mir-187 quantitative PCR miRNA overexpression 53.7
6 hsa-mir-197 quantitative PCR miRNA overexpression 7.2
7 hsa-mir-221 quantitative PCR miRNA overexpression 46.9
8 hsa-mir-222 quantitative PCR miRNA overexpression 26
9 hsa-mir-339 quantitative PCR miRNA overexpression 42.5
10 hsa-mir-96 quantitative PCR miRNA overexpression 10.3

Detailed information about selected miRNA


hsa-mir-181a-1
quantitative PCR
miRNA overexpression
14.3    

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment

Comments


General comment: In the article, only results of the 10 most upregulated miRNAs are presented. In fact, in the majority of thyroid tumors, 47 of 148 miRNAs (32%) were consistently up-regulated when compared with normal tissue, and 57 of 148 (38%) were down-regulated with more than a 2-fold change.