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General information

Homo sapiens (9606)
Thyroid carcinoma, follicular
Follicular thyroid carcinoma, oncocytic
Most thyroid carcinomas originate from thyroid follicular cells and are subdivided into well-differentiated papillary carcinoma (PC) and follicular carcinoma (FC) (the latter further subclassified into conventional and oncocytic type). Both PCs and FCs may progress to poorly differentiated carcinoma (PDC) or may completely lose differentiation to give rise to anaplastic carcinoma (AC). Follicular adenomas (FAs) are benign thyroid tumors and can be of either conventional type or oncocytic type. Less than 5% of cells within the thyroid gland are C-cells that give rise to medullary carcinoma (MC).

Study information

Patient study phenotype-control
The number of patients was not explicitly mentioned.
thyroid gland

miRNA list

Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-96 quantitative PCR miRNA overexpression 10.3
2 hsa-mir-339 quantitative PCR miRNA overexpression 42.5
3 hsa-mir-222 quantitative PCR miRNA overexpression 26
4 hsa-mir-221 quantitative PCR miRNA overexpression 46.9
5 hsa-mir-197 quantitative PCR miRNA overexpression 7.2
6 hsa-mir-187 quantitative PCR miRNA overexpression 53.7
7 hsa-mir-183 quantitative PCR miRNA overexpression 26.6
8 hsa-mir-182 quantitative PCR miRNA overexpression 15.6
9 hsa-mir-181b-1 quantitative PCR miRNA overexpression 19.7
10 hsa-mir-181a-1 quantitative PCR miRNA overexpression 14.3

Detailed information about selected miRNA

quantitative PCR
miRNA overexpression

Genes associated with selected miRNA

target gene regulation mechanism of regulation comment


General comment: In the article, only results of the 10 most upregulated miRNAs are presented. In fact, in the majority of thyroid tumors, 47 of 148 miRNAs (32%) were consistently up-regulated when compared with normal tissue, and 57 of 148 (38%) were down-regulated with more than a 2-fold change.