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General information


100
18270258
Homo sapiens (9606)
disease
Thyroid carcinoma, papillary
Most thyroid carcinomas originate from thyroid follicular cells and are subdivided into well-differentiated papillary carcinoma (PC) and follicular carcinoma (FC) (the latter further subclassified into conventional and oncocytic type). Both PCs and FCs may progress to poorly differentiated carcinoma (PDC) or may completely lose differentiation to give rise to anaplastic carcinoma (AC). Follicular adenomas (FAs) are benign thyroid tumors and can be of either conventional type or oncocytic type. Less than 5% of cells within the thyroid gland are C-cells that give rise to medullary carcinoma (MC).

Study information


Patient study phenotype-control
9
5
thyroid gland

miRNA list


Nr miRNA Method Further methods Evidence Foldchange Genes
1 hsa-mir-122 quantitative PCR miRNA overexpression 8.9
2 hsa-mir-146b quantitative PCR miRNA overexpression 10.5
3 hsa-mir-155 quantitative PCR miRNA overexpression 9.5
4 hsa-mir-181b-1 quantitative PCR miRNA overexpression 14.4
5 hsa-mir-187 quantitative PCR miRNA overexpression 73.7
6 hsa-mir-205 quantitative PCR miRNA overexpression 6.8
7 hsa-mir-221 quantitative PCR miRNA overexpression 19.1
8 hsa-mir-222 quantitative PCR miRNA overexpression 17.2
9 hsa-mir-224 quantitative PCR miRNA overexpression 6.2
10 hsa-mir-31 quantitative PCR miRNA overexpression 7.5

Detailed information about selected miRNA


hsa-mir-122
quantitative PCR
miRNA overexpression
8.9    

Genes associated with selected miRNA


target gene regulation mechanism of regulation comment

Comments


General comment: In the article, only results of the 10 most upregulated miRNAs are presented. In fact, in the majority of thyroid tumors, 47 of 148 miRNAs (32%) were consistently up-regulated when compared with normal tissue, and 57 of 148 (38%) were down-regulated with more than a 2-fold change.