The PhenomiR database provides information about differentially regulated miRNA expression in diseases and
other biological processes.
The content of PhenomiR is completely generated by manual curation of experienced annotators. Data was
extracted from more than 365 scientific articles and resulted in more than 632 database entries as
of 02 2011.
The design principle of PhenomiR is to use established ontologies and resources. For annotation of
diseases we use information of the OMIM Morbid Map, bioprocesses are described with terms from Gene
Ontology and for annotation of tissue/cell culture information the Tissue Ontology is used.
Ruepp A, Kowarsch A, Schmidl D, Buggenthin F, Brauner B, Dunger I, Fobo G, Frishman G, Montrone C, Theis FJ. PhenomiR: a knowledgebase for microRNA expression in diseases and biological processes. Genome Biology 2010, 11:R6
The graph displays the connected part of the cancer network extracted from the PhenomiR database where
only miRNAs with a minimal degree of 2 and a maximal degree of 5 were taken into consideration.
All miRNAs are shown as small color coded octagons; the color coding indicates the number of carcinomal
disorders a specific miRNA is involved in and reaches from light blue for 2 disorders to dark blue for 5.
Furthermore, the disorders, shown as green ellipses, are linked to the according entries within the database.