Abnormality of the metacarpal bones

Symptom Information:

Symptom ID: HPO:0001163
Cross references:
Is a (Direct Parents):
HPO         Abnormality of the hand
Is a (Whole tree): HPO:
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the skeletal system(HPO:0000924)
          Abnormality of skeletal morphology(HPO:0011842)
             Abnormal appendicular skeleton morphology(HPO:0011844)
                Abnormality of limb bone morphology(HPO:0002813)
                   Abnormality of the upper limb(HPO:0002817)
                      Abnormality of the hand(HPO:0001155)
                         Abnormality of the metacarpal bones(HPO:0001163)
Database Frequency: 149 / 7739

All diseases associated with this symptom:

14q22q23 microdeletion syndrome (Orphanet:264200)
2q31.1 microdeletion syndrome (Orphanet:251014)
2q37 microdeletion syndrome (Orphanet:1001)
8q21.11 microdeletion syndrome (Orphanet:284160)
Absent thumb - short stature - immunodeficiency (Orphanet:2951)
Acro-cardio-facial syndrome (Orphanet:2008)
Acro-oto-ocular syndrome (Orphanet:2980)
Acrocapitofemoral dysplasia (Orphanet:63446)
Acrocraniofacial dysostosis (Orphanet:949)
Acrodysostosis (Orphanet:950)
Acrofacial dysostosis, Palagonia type (Orphanet:1787)
Acromegaloid facial appearance syndrome (Orphanet:965)
Acromesomelic dysplasia, Grebe type (Orphanet:2098)
Acromicric dysplasia (Orphanet:969)
Adams-Oliver syndrome (Orphanet:974)
Albers-Schönberg osteopetrosis (Orphanet:53)
Aphalangy - hemivertebrae - urogenital-intestinal dysgenesis (Orphanet:1112)
Aphalangy - syndactyly - microcephaly (Orphanet:1113)
Atrioventricular defect - blepharophimosis -radial defects (Orphanet:1352)
Auriculoosteodysplasia (Orphanet:114)
Autosomal dominant omodysplasia (Orphanet:93328)
Baller-Gerold syndrome (Orphanet:1225)
Banki syndrome (Orphanet:1228)
Bannayan-Riley-Ruvalcaba syndrome (Orphanet:109)
Blepharophimosis - radioulnar synostosis (Orphanet:1256)
Boomerang dysplasia (Orphanet:1263)
Brachydactyly - arterial hypertension (Orphanet:1276)
Brachydactyly - nystagmus - cerebellar ataxia (Orphanet:1246)
Brachydactyly - preaxial hallux varus (Orphanet:1278)
Brachydactyly type A1 (Orphanet:93388)
Brachydactyly type A2 (Orphanet:93396)
Brachydactyly type B (Orphanet:93383)
Brachydactyly type C (Orphanet:93384)
Brachydactyly type E (Orphanet:93387)
Brachydactyly-syndactyly, Zhao type (Orphanet:93409)
Brachytelephalangy - dysmorphism - Kallmann syndrome (Orphanet:1295)
CODAS syndrome (Orphanet:1458)
Cenani-Lenz syndrome (Orphanet:3258)
Charlie M syndrome (Orphanet:1406)
Chondrodysplasia - disorder of sex development (Orphanet:1422)
Chondrodysplasia, Blomstrand type (Orphanet:50945)
Cleft palate - short stature - vertebral anomalies (Orphanet:2015)
Coffin-Lowry syndrome (Orphanet:192)
Congenital absence/hypoplasia of fingers excluding thumb, unilateral (Orphanet:973)
Cornelia de Lange syndrome (Orphanet:199)
Crouzon syndrome - acanthosis nigricans (Orphanet:93262)
Deafness - genital anomalies - metacarpal and metatarsal synostosis (Orphanet:3224)
Dermato-cardio-skeletal syndrome, Borrone type (Orphanet:1266)
Diastrophic dwarfism (Orphanet:628)
Distal limb deficiencies - micrognathia syndrome (Orphanet:1307)
Distal monosomy 13q (Orphanet:1590)
Distal monosomy 17q (Orphanet:1597)
Dyggve-Melchior-Clausen disease (Orphanet:239)
Ectrodactyly - polydactyly (Orphanet:1892)
Fountain syndrome (Orphanet:3219)
Fuhrmann syndrome (Orphanet:2854)
Geleophysic dysplasia (Orphanet:2623)
Gorlin syndrome (Orphanet:377)
Gorlin-Chaudhry-Moss syndrome (Orphanet:2095)
Hand-foot-genital syndrome (Orphanet:2438)
Heart-hand syndrome type 2 (Orphanet:1350)
Heart-hand syndrome type 3 (Orphanet:1342)
Hereditary acrokeratotic poikiloderma, Weary type (Orphanet:2907)
Holt-Oram syndrome (Orphanet:392)
Holzgreve-Wagner-Rehder syndrome (Orphanet:2167)
Humero-radio-ulnar synostosis (Orphanet:3266)
Hurler-Scheie syndrome (Orphanet:93476)
Hypogonadism - mitral valve prolapse - intellectual deficit (Orphanet:2233)
Intellectual deficit - sparse hair - brachydactyly (Orphanet:3051)
Isolated brachycephaly (Orphanet:35099)
Joubert syndrome with orofaciodigital defect (Orphanet:2754)
Juberg-Hayward syndrome (Orphanet:2319)
Karsch-Neugebauer syndrome (Orphanet:2329)
Kindler syndrome (Orphanet:2908)
Larsen-like osseous dysplasia - short stature (Orphanet:2370)
Laurin-Sandrow syndrome (Orphanet:2378)
Lenz-Majewski hyperostotic dwarfism (Orphanet:2658)
Leri pleonosteosis (Orphanet:2900)
Léri-Weill dyschondrosteosis (Orphanet:240)
Marinesco-Sjögren syndrome (Orphanet:559)
McKusick-Kaufman syndrome (Orphanet:2473)
Mesoaxial synostotic syndactyly with phalangeal reduction (Orphanet:157801)
Mesomelia-synostoses syndrome (Orphanet:2496)
Mesomelic dwarfism - cleft palate - camptodactyly (Orphanet:2631)
Metaphyseal acroscyphodysplasia (Orphanet:1240)
Microbrachycephaly - ptosis - cleft lip (Orphanet:2511)
Microcephalic osteodysplastic primordial dwarfism types 1 and 3 (Orphanet:2636)
Microgastria - limb reduction defect (Orphanet:2538)
Microphthalmia with limb anomalies (Orphanet:1106)
Moebius syndrome (Orphanet:570)
Mononen-Karnes-Senac syndrome (Orphanet:2565)
Multicentric carpo-tarsal osteolysis with or without nephropathy (Orphanet:2774)
Nance-Horan syndrome (Orphanet:627)
Neurofaciodigitorenal syndrome (Orphanet:2673)
Non-rhizomelic chondrodysplasia punctata (Orphanet:176)
Oculo-skeletal-renal syndrome (Orphanet:2716)
Orofaciodigital syndrome type 2 (Orphanet:2751)
Osteocraniostenosis (Orphanet:2763)
Osteodysplasty, Melnick-Needles type (Orphanet:2484)
Otopalatodigital syndrome (Orphanet:669)
Otopalatodigital syndrome type 1 (Orphanet:90650)
Otopalatodigital syndrome type 2 (Orphanet:90652)
Paraplegia - brachydactyly - cone-shaped epiphysis (Orphanet:2823)
Phocomelia - ectrodactyly - deafness - sinus arrhythmia (Orphanet:2878)
Platyspondylic dysplasia, Torrance type (Orphanet:85166)
Postaxial tetramelic oligodactyly (Orphanet:2730)
Proximal symphalangism (Orphanet:3250)
Pseudoachondroplasia (Orphanet:750)
Radial ray hypoplasia - choanal atresia (Orphanet:3026)
Refsum disease (Orphanet:773)
Renal-genital-middle ear anomalies (Orphanet:1092)
Rhizomelic dysplasia, Patterson-Lowry type (Orphanet:2831)
Richieri Costa-Pereira syndrome (Orphanet:3102)
Roberts syndrome (Orphanet:3103)
Robin sequence - oligodactyly (Orphanet:3104)
Rothmund-Thomson syndrome (Orphanet:2909)
Ruvalcaba syndrome (Orphanet:3121)
SPONASTRIME dysplasia (Orphanet:93357)
Schinzel-Giedion syndrome (Orphanet:798)
Shoulder and girdle defects - familial intellectual deficit (Orphanet:2580)
Smith-Lemli-Opitz syndrome (Orphanet:818)
Spondyloepimetaphyseal dysplasia with multiple dislocations (Orphanet:93360)
Spondyloepimetaphyseal dysplasia, Irapa type (Orphanet:93351)
Spondylometaphyseal dysplasia, 'corner fracture' type (Orphanet:93315)
Spondylometaphyseal dysplasia, Sedaghatian type (Orphanet:93317)
Spondyloperipheral dysplasia - short ulna (Orphanet:1856)
Stern-Lubinsky-Durrie syndrome (Orphanet:3194)
Stickler syndrome type 3 (Orphanet:166100)
Summitt syndrome (Orphanet:3210)
Syndactyly type 2 (Orphanet:93403)
Syndactyly type 4 (Orphanet:93405)
Syndactyly type 5 (Orphanet:93406)
Syndactyly type 8 (Orphanet:2498)
Syndrome with brachydactyly (Orphanet:69028)
Talo-patello-scaphoid osteolysis (Orphanet:50809)
Tel Hashomer camptodactyly syndrome (Orphanet:3292)
Thumb stiffness - brachydactyly - intellectual deficit (Orphanet:1078)
Tricho-odonto-onychodysplasia - dominant syndactyly (Orphanet:3357)
Triphalangeal thumb - polysyndactyly syndrome (Orphanet:2950)
Trisomy 5p (Orphanet:1742)
Turner syndrome (Orphanet:881)
Ulna metaphyseal dysplasia syndrome (Orphanet:1837)
Ulnar-mammary syndrome (Orphanet:3138)
Upper limb defect - eye and ear abnormalities (Orphanet:2489)
Van den Ende-Gupta syndrome (Orphanet:2460)
Ventricular extrasystoles with syncopal episodes - perodactyly - Robin sequence (Orphanet:3201)
Verloove Vanhorick-Brubakk syndrome (Orphanet:3429)
WT limb-blood syndrome (Orphanet:3466)
X-linked dominant chondrodysplasia, Chassaing-Lacombe type (Orphanet:163966)