Fatigable weakness

Symptom Information:

Symptom ID: HPO:0003473
Synonyms:
Fatigable weakness of limb muscles [HPO:0003473]
Generalized muscle weakness due to defect at the neuromuscular junction [HPO:0003473]
Myasthenia [HPO:0003473]
Myasthenic weakness [HPO:0003473]
Proximal muscle weakness due to defect at the neuromuscular junction [HPO:0003473]
Myasthenia [Orphanet:43170]
Asthenia [Orphanet:54350]
Lack of energy (finding) [Orphanet:54350]
Fatigue (finding) [Orphanet:54350]
Asthenia (finding) [Orphanet:54350]
Myasthenias [Orphanet:43170]
Fatigue [Orphanet:54350]
Generalized muscle weakness due to defect at the neuromuscular junction [OMIM:Generalized muscle weakness due to defect at the neuromuscular junction]
Proximal muscle weakness due to defect at the neuromuscular junction [OMIM:Proximal muscle weakness due to defect at the neuromuscular junction]
Asthenia/fatigue/weakness [Orphanet:54350]
Asthenia [MedDRA:10003549]
Adynamia [MedDRA:10003549]
Collapse of legs [MedDRA:10003549]
Debility [MedDRA:10003549]
Debility marked [MedDRA:10003549]
Debility, unspecified [MedDRA:10003549]
Feeling of total lack of energy [MedDRA:10003549]
Feelings of weakness [MedDRA:10003549]
General debility [MedDRA:10003549]
Loss of energy [MedDRA:10003549]
Nervous debility [MedDRA:10003549]
Neurasthaenia [MedDRA:10003549]
Neurasthenia [MedDRA:10003549]
Strength loss of [MedDRA:10003549]
Weakness [MedDRA:10003549]
Weakness generalised [MedDRA:10003549]
Weakness generalized [MedDRA:10003549]
Weakness postural [MedDRA:10003549]
Physical deconditioning [MedDRA:10003549]
Energy decreased [MedDRA:10003549]
Frailty [MedDRA:10003549]
Weakness worsened [MedDRA:10003549]
Hyposthenia [MedDRA:10003549]
Fatigue [MedDRA:10016256]
Enervation [MedDRA:10016256]
Exhaustion [MedDRA:10016256]
Exhaustion due to excessive exertion [MedDRA:10016256]
Exhaustion due to exposure [MedDRA:10016256]
Fatigability [MedDRA:10016256]
Fatigability generalized [MedDRA:10016256]
Fatigability lumbar [MedDRA:10016256]
Fatigability of knees [MedDRA:10016256]
Fatigue extreme [MedDRA:10016256]
Fatiguability [MedDRA:10016256]
Lassitude [MedDRA:10016256]
Loss physical strength [MedDRA:10016256]
Prostration [MedDRA:10016256]
TATT [MedDRA:10016256]
Tired all the time [MedDRA:10016256]
Tired and heavy [MedDRA:10016256]
Tired out [MedDRA:10016256]
Tiredness [MedDRA:10016256]
Washed-out [MedDRA:10016256]
Weariness [MedDRA:10016256]
Worn out [MedDRA:10016256]
Fatigue aggravated [MedDRA:10016256]
Depressive weariness [MedDRA:10016256]
Fatigueability generalised [MedDRA:10016256]
Chronic fatigue [MedDRA:10016256]
Fatiguability generalised [MedDRA:10016256]
Exhaustion [OMIM:Exhaustion]
Fatigue (1 patient) [OMIM:Fatigue (1 patient)]
Generalized weakness (adult-onset) [OMIM:Generalized weakness (adult-onset)]
Lassitude [OMIM:Lassitude]
Weakness, generalized [OMIM:Weakness, generalized]
Quality:
Cross references:
Orphanet:43170 "Myasthenia" [Orphanet:43170]
Orphanet:54350 "Asthenia/fatigue/weakness" [Orphanet:54350]
OMIM: "Generalized muscle weakness due to defect at the neuromuscular junction" [OMIM:Generalized muscle weakness due to defect at the neuromuscular junction]
OMIM: "Proximal muscle weakness due to defect at the neuromuscular junction" [OMIM:Proximal muscle weakness due to defect at the neuromuscular junction]
OMIM: "Exhaustion" [OMIM:Exhaustion]
OMIM: "Fatigue (1 patient)" [OMIM:Fatigue (1 patient)]
OMIM: "Generalized weakness (adult-onset)" [OMIM:Generalized weakness (adult-onset)]
OMIM: "Lassitude" [OMIM:Lassitude]
OMIM: "Weakness, generalized" [OMIM:Weakness, generalized]
UMLS:C0947912 "Myasthenias" [Orphanet:43170]
UMLS:C0004093 "Asthenia" [Orphanet:54350]
UMLS:C0015672 "Fatigue" [Orphanet:54350]
Is a (Direct Parents):
HPO         Abnormal synaptic transmission at the neuromuscular junction
Orphanet Health status anomalies
HPO         Fatigable weakness of skeletal muscles
MedDRA Asthenic conditions
Orphanet Functional anomalies of the nervous system
HPO         Muscle weakness
HPO         Fatigable weakness of bulbar muscles
HPO         Fatigable weakness of respiratory muscles
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the nervous system(HPO:0000707)
          Abnormality of nervous system morphology(HPO:0012639)
             Abnormal peripheral nervous system morphology(HPO:0000759)
                Abnormal synaptic transmission at the neuromuscular junction(HPO:0003398)
                   Fatigable weakness(HPO:0003473)
       Abnormality of the musculature(HPO:0003011)
          Abnormality of muscle physiology(HPO:0011804)
             Muscle weakness(HPO:0001324)
                Fatigable weakness(HPO:0003473)
MedDRA:
General disorders and administration site conditions(MedDRA:10018065)
    General system disorders NEC(MedDRA:10018073)
       Asthenic conditions(MedDRA:10003550)
          Fatigable weakness(HPO:0003473)
Database Frequency: 39 / 7739
Resource:

All diseases associated with this symptom:

AL amyloidosis (Orphanet:85443)
Autosomal dominant hypophosphatemic rickets (Orphanet:89937)
CLUSTER HEADACHE, FAMILIAL (OMIM:119915)
Congenital myasthenic syndromes (Orphanet:590)
Congenital myasthenic syndromes with glycosylation defect (Orphanet:353327)
Cushing disease (Orphanet:96253)
Cushing syndrome (Orphanet:553)
Cystinosis (Orphanet:213)
EDEMA, FAMILIAL IDIOPATHIC, PREPUBERTAL (OMIM:129840)
Epidermolysis bullosa simplex with anodontia/hypodontia (Orphanet:2325)
Epidermolysis bullosa simplex with muscular dystrophy (Orphanet:257)
Generalized epidermolysis bullosa simplex, non-Dowling-Meara type (Orphanet:79399)
Good syndrome (Orphanet:169105)
Hemochromatosis type 3 (Orphanet:225123)
Lymphangioleiomyomatosis (Orphanet:538)
MELAS (Orphanet:550)
MYASTHENIA GRAVIS (OMIM:254200)
MYASTHENIA, LIMB-GIRDLE, AUTOIMMUNE (OMIM:159400)
MYASTHENIC SYNDROME, CONGENITAL, 10 (OMIM:254300)
MYASTHENIC SYNDROME, CONGENITAL, 12 (OMIM:610542)
MYASTHENIC SYNDROME, CONGENITAL, 14 (OMIM:616228)
MYASTHENIC SYNDROME, CONGENITAL, 15 (OMIM:616227)
MYASTHENIC SYNDROME, CONGENITAL, 16 (OMIM:614198)
MYASTHENIC SYNDROME, CONGENITAL, 1A, SLOW-CHANNEL (OMIM:601462)
MYASTHENIC SYNDROME, CONGENITAL, 4A, SLOW-CHANNEL (OMIM:605809)
MYASTHENIC SYNDROME, CONGENITAL, 4C, ASSOCIATED WITH ACETYLCHOLINERECEPTOR DEFICIENCY (OMIM:608931)
Menkes disease (Orphanet:565)
Mitochondrial myopathy with reversible cytochrome C oxidase deficiency (Orphanet:254864)
Multiple acyl-CoA dehydrogenase deficiency (Orphanet:26791)
Myasthenia gravis (Orphanet:589)
PGM1-CDG (Orphanet:319646)
Postsynaptic congenital myasthenic syndromes (Orphanet:98913)
Presynaptic congenital myasthenic syndromes (Orphanet:98914)
Primary systemic amyloidosis (Orphanet:314701)
Synaptic congenital myasthenic syndromes (Orphanet:98915)
Thymic carcinoma (Orphanet:99868)
Thymic epithelial neoplasm (Orphanet:3398)
Thymic tumor (Orphanet:100100)
Thymoma (Orphanet:99867)