Increased susceptibility to fractures

Symptom Information:

Symptom ID: HPO:0002659
Synonyms:
Abnormal susceptibility to fractures [HPO:0002659]
Bone fragility [HPO:0002659]
Increased bone fragility [HPO:0002659]
Increased tendency to fractures [HPO:0002659]
Bone fragility [Orphanet:45270]
Bone fragile [Orphanet:45270]
Bone fragility [OMIM:Bone fragility]
Increased bone fragility [OMIM:Increased bone fragility]
Increased susceptibility to fractures [OMIM:Increased susceptibility to fractures]
Mutiple fractures/bone fragility [Orphanet:45270]
Osteoporosis [MedDRA:10031282]
Bone fragile [MedDRA:10031282]
Disuse osteoporosis [MedDRA:10031282]
Idiopathic osteoporosis [MedDRA:10031282]
Osteoporosis NOS [MedDRA:10031282]
Osteoporosis steroid-induced [MedDRA:10031282]
Osteoporosis, unspecified [MedDRA:10031282]
Other osteoporosis [MedDRA:10031282]
Osteoporomalacia [MedDRA:10031282]
Fragile bones [OMIM:Fragile bones]
Osteoporosis (70% of patients) [OMIM:Osteoporosis (70% of patients)]
Osteoporosis (classic feature) [OMIM:Osteoporosis (classic feature)]
Osteoporosis (in some patients) [OMIM:Osteoporosis (in some patients)]
Osteoporosis (onset in childhood) [OMIM:Osteoporosis (onset in childhood)]
Quality:
Cross references:
Orphanet:45270 "Mutiple fractures/bone fragility" [Orphanet:45270]
OMIM: "Bone fragility" [OMIM:Bone fragility]
OMIM: "Increased bone fragility" [OMIM:Increased bone fragility]
OMIM: "Increased susceptibility to fractures" [OMIM:Increased susceptibility to fractures]
OMIM: "Fragile bones" [OMIM:Fragile bones]
OMIM: "Osteoporosis (70% of patients)" [OMIM:Osteoporosis (70% of patients)]
OMIM: "Osteoporosis (classic feature)" [OMIM:Osteoporosis (classic feature)]
OMIM: "Osteoporosis (in some patients)" [OMIM:Osteoporosis (in some patients)]
OMIM: "Osteoporosis (onset in childhood)" [OMIM:Osteoporosis (onset in childhood)]
UMLS:C0858714 "Bone fragile" [Orphanet:45270]
Is a (Direct Parents):
HPO         Abnormality of skeletal physiology
MedDRA Metabolic bone disorders
Orphanet Abnormality of the skeletal system
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the skeletal system(HPO:0000924)
          Abnormality of skeletal physiology(HPO:0011843)
             Increased susceptibility to fractures(HPO:0002659)
MedDRA:
Musculoskeletal and connective tissue disorders(MedDRA:10028395)
    Bone disorders (excl congenital and fractures)(MedDRA:10005959)
       Metabolic bone disorders(MedDRA:10027425)
          Increased susceptibility to fractures(HPO:0002659)
Database Frequency: 110 / 7739
Resource:

All diseases associated with this symptom:

Achondrogenesis type 1A (Orphanet:93299)
Acroosteolysis, dominant type (Orphanet:955)
Adamantinoma (Orphanet:55881)
Aggressive systemic mastocytosis (Orphanet:98850)
Albers-Schönberg osteopetrosis (Orphanet:53)
Albright hereditary osteodystrophy (Orphanet:665)
Antley-Bixler syndrome (Orphanet:83)
Arthrogryposis - renal dysfunction - cholestasis (Orphanet:2697)
Autosomal dominant hyper-IgE syndrome (Orphanet:2314)
Autosomal dominant hypophosphatemic rickets (Orphanet:89937)
Autosomal recessive cutis laxa type 1 (Orphanet:90349)
Autosomal recessive malignant osteopetrosis (Orphanet:667)
BRUCK SYNDROME 1 (OMIM:259450)
BRUCK SYNDROME 2 (OMIM:609220)
Berardinelli-Seip congenital lipodystrophy (Orphanet:528)
Bowed tibiae - radial anomalies - osteopenia - fractures (Orphanet:3331)
Brittle cornea syndrome (Orphanet:90354)
Bruck syndrome (Orphanet:2771)
Buschke-Ollendorff syndrome (Orphanet:1306)
CELIAC DISEASE, SUSCEPTIBILITY TO, 1 (OMIM:212750)
CLEIDOCRANIAL DYSPLASIA (OMIM:119600)
Campomelic dysplasia (Orphanet:140)
Classical homocystinuria (Orphanet:394)
Cleidocranial dysplasia (Orphanet:1452)
Cole-Carpenter syndrome (Orphanet:2050)
Congenital erythropoietic porphyria (Orphanet:79277)
Congenital osteogenesis imperfecta - microcephaly - cataracts (Orphanet:2772)
Cushing disease (Orphanet:96253)
Cushing syndrome (Orphanet:553)
Cushing syndrome due to ectopic ACTH secretion (Orphanet:99889)
Cutaneous mastocytosis (Orphanet:66646)
DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE, 1 (OMIM:224230)
Dermatitis herpetiformis (Orphanet:1656)
Dominant hypophosphatemia with nephrolithiasis or osteoporosis (Orphanet:244305)
Dyskeratosis congenita (Orphanet:1775)
Dysosteosclerosis (Orphanet:1782)
Dysplasia epiphysealis hemimelica (Orphanet:1822)
Ehlers-Danlos syndrome, arthrochalasic type (Orphanet:1899)
Eosinophilic granuloma (Orphanet:99871)
Familial dysautonomia (Orphanet:1764)
Familial osteodysplasia, Anderson type (Orphanet:2769)
Gaucher disease (Orphanet:355)
Gaucher disease type 1 (Orphanet:77259)
Gaucher disease type 3 (Orphanet:77261)
Geroderma osteodysplastica (Orphanet:2078)
Gnathodiaphyseal dysplasia (Orphanet:53697)
Grange syndrome (Orphanet:79094)
HYPOGONADOTROPIC HYPOGONADISM 18 WITH OR WITHOUT ANOSMIA (OMIM:615267)
HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA (OMIM:615269)
HYPOGONADOTROPIC HYPOGONADISM 20 WITH OR WITHOUT ANOSMIA (OMIM:615270)
HYPOGONADOTROPIC HYPOGONADISM 21 WITH OR WITHOUT ANOSMIA (OMIM:615271)
Hallermann-Streiff syndrome (Orphanet:2108)
Hypocalcemic vitamin D-resistant rickets (Orphanet:93160)
Hypophosphatasia (Orphanet:436)
Idiopathic juvenile osteoporosis (Orphanet:85193)
Juvenile Paget disease (Orphanet:2801)
Kallmann syndrome (Orphanet:478)
LOEYS-DIETZ SYNDROME 2 (OMIM:610168)
Lethal congenital contracture syndrome type 1 (Orphanet:1486)
Lethal multiple pterygium syndrome (Orphanet:33108)
Lichstenstein syndrome (Orphanet:2390)
Maffucci syndrome (Orphanet:163634)
Majeed syndrome (Orphanet:77297)
Marshall-Smith syndrome (Orphanet:561)
Mastocytosis (Orphanet:98292)
Mazabraud syndrome (Orphanet:57782)
McCune-Albright syndrome (Orphanet:562)
Menkes disease (Orphanet:565)
Metaphyseal dysplasia - maxillary hypoplasia - brachydacty (Orphanet:2504)
Microspherophakia - metaphyseal dysplasia (Orphanet:2551)
Mohr-Tranebjaerg syndrome (Orphanet:52368)
Monosomy 5p (Orphanet:281)
Multiple non-ossifying fibromatosis (Orphanet:2029)
Multiple osteochondromas (Orphanet:321)
NEPHROLITHIASIS/OSTEOPOROSIS, HYPOPHOSPHATEMIC, 1 (OMIM:612286)
NEPHROLITHIASIS/OSTEOPOROSIS, HYPOPHOSPHATEMIC, 2 (OMIM:612287)
Navajo neurohepatopathy (Orphanet:255229)
Neonatal severe primary hyperparathyroidism (Orphanet:417)
OSTEOGENESIS IMPERFECTA, TYPE VI (OMIM:613982)
OSTEOGENESIS IMPERFECTA, TYPE VIII (OMIM:610915)
OSTEOGENESIS IMPERFECTA, TYPE XI (OMIM:610968)
Oculocerebrorenal syndrome (Orphanet:534)
Osteocraniostenosis (Orphanet:2763)
Osteogenesis imperfecta (Orphanet:666)
Osteogenesis imperfecta - retinopathy - seizures - intellectual deficit (Orphanet:2773)
Osteogenesis imperfecta type 1 (Orphanet:216796)
Osteoglophonic dwarfism (Orphanet:2645)
Osteopenia - myopia - hearing loss - intellectual deficit - facial dysmorphism (Orphanet:91133)
Osteopetrosis (Orphanet:2781)
Osteopetrosis with renal tubular acidosis (Orphanet:2785)
Osteoporosis - pseudoglioma (Orphanet:2788)
PAGET DISEASE OF BONE (OMIM:602080)
Perinatal lethal hypophosphatasia (Orphanet:247623)
Primary hyperoxaluria (Orphanet:416)
Primary pigmented nodular adrenocortical disease (Orphanet:189439)
Proximal spinal muscular atrophy (Orphanet:70)
Pycnodysostosis (Orphanet:763)
Pyle disease (Orphanet:3005)
SAPHO syndrome (Orphanet:793)
Sakati-Nyhan syndrome (Orphanet:3128)
Segmental outgrowth - lipomatosis - arteriovenous malformation - epidermal nevus (Orphanet:137608)
Spondylometaphyseal dysplasia, 'corner fracture' type (Orphanet:93315)
Stüve-Wiedemann syndrome (Orphanet:3206)
Suarez-Stickler syndrome (Orphanet:166277)
Systemic mastocytosis (Orphanet:2467)
Urban-Rogers-Meyer syndrome (Orphanet:3409)
Wolcott-Rallison syndrome (Orphanet:1667)
X-linked hypophosphatemia (Orphanet:89936)
X-linked lethal multiple pterygium syndrome (Orphanet:79447)
Yunis-Varon syndrome (Orphanet:3472)