Neurological speech impairment

Symptom Information:

Symptom ID: HPO:0002167
Speech disorder [HPO:0002167]
Speech impairment [HPO:0002167]
Speech impediment [HPO:0002167]
Speech disorder [OMIM:Speech disorder]
Speech impairment [OMIM:Speech impairment]
Speech disorder (in 1 of 6 patients) [OMIM:Speech disorder (in 1 of 6 patients)]
Speech disorders (rare) [OMIM:Speech disorders (rare)]
Speech disorder [MedDRA:10041466]
Impaired speech [OMIM,du]
Cross references:
OMIM: "Speech disorder" [OMIM:Speech disorder]
OMIM: "Speech impairment" [OMIM:Speech impairment]
OMIM: "Speech disorder (in 1 of 6 patients)" [OMIM:Speech disorder (in 1 of 6 patients)]
OMIM: "Speech disorders (rare)" [OMIM:Speech disorders (rare)]
Is a (Direct Parents):
HPO         Abnormality of higher mental function
MedDRA Speech and language usage disturbances
Is a (Whole tree): HPO:
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the nervous system(HPO:0000707)
          Abnormality of nervous system physiology(HPO:0012638)
             Abnormality of higher mental function(HPO:0011446)
                Neurological speech impairment(HPO:0002167)
Database Frequency: 308 / 7739

All diseases associated with this symptom:

10q22.3q23.3 microdeletion syndrome (Orphanet:276413)
10q22.3q23.3 microduplication syndrome (Orphanet:276422)
12q14 microdeletion syndrome (Orphanet:94063)
14q12 microdeletion syndrome (Orphanet:261144)
15q11q13 microduplication syndrome (Orphanet:238446)
15q14 microdeletion syndrome (Orphanet:261190)
16p11.2p12.2 microdeletion syndrome (Orphanet:261211)
16p11.2p12.2 microduplication syndrome (Orphanet:261204)
16p13.11 microduplication syndrome (Orphanet:261243)
16q24.3 microdeletion syndrome (Orphanet:261250)
17p11.2 microduplication syndrome (Orphanet:1713)
17q11.2 microduplication syndrome (Orphanet:139474)
17q12 microdeletion syndrome (Orphanet:261265)
17q12 microduplication syndrome (Orphanet:261272)
17q21.31 microduplication syndrome (Orphanet:217340)
17q23.1q23.2 microdeletion syndrome (Orphanet:261279)
19p13.12 microdeletion syndrome (Orphanet:254346)
19q13.11 microdeletion syndrome (Orphanet:217346)
1p36 deletion syndrome (Orphanet:1606)
1q44 microdeletion syndrome (Orphanet:238769)
22q11.2 deletion syndrome (Orphanet:567)
22q11.2 microduplication syndrome (Orphanet:1727)
2p15p16.1 microdeletion syndrome (Orphanet:261349)
2p21 microdeletion syndrome (Orphanet:163693)
2q23.1 microdeletion syndrome (Orphanet:228402)
2q31.1 microdeletion syndrome (Orphanet:251014)
2q32q33 microdeletion syndrome (Orphanet:251019)
3-methylglutaconic aciduria type 3 (Orphanet:67047)
3C syndrome (Orphanet:7)
3q29 microdeletion syndrome (Orphanet:65286)
48,XXXY syndrome (Orphanet:96263)
48,XXYY syndrome (Orphanet:10)
49,XXXXY syndrome (Orphanet:96264)
4q21 microdeletion syndrome (Orphanet:238750)
5q14.3 microdeletion syndrome (Orphanet:228384)
6q16 deletion syndrome (Orphanet:171829)
8p23.1 microdeletion syndrome (Orphanet:251071)
8p23.1 microduplication syndrome (Orphanet:251076)
Ablepharon macrostomia syndrome (Orphanet:920)
Aceruloplasminemia (Orphanet:48818)
Achondroplasia (Orphanet:15)
Acro-oto-ocular syndrome (Orphanet:2980)
Acromesomelic dysplasia, Hunter-Thomson type (Orphanet:968)
Acroosteolysis, dominant type (Orphanet:955)
Adenylosuccinate lyase deficiency (Orphanet:46)
Adult-onset autosomal dominant leukodystrophy (Orphanet:99027)
Albinism-deafness syndrome (Orphanet:998)
Alexander disease (Orphanet:58)
Allan-Herndon-Dudley syndrome (Orphanet:59)
Alopecia antibody deficiency (Orphanet:1006)
Alpha-mannosidosis (Orphanet:61)
Alpha-thalassemia - X-linked intellectual deficit syndrome (Orphanet:847)
Alpha-thalassemia - intellectual deficit syndrome linked to chromosome 16 (Orphanet:98791)
Alveolar echinococcosis (Orphanet:284)
Angelman syndrome (Orphanet:72)
Aniridia - cerebellar ataxia - intellectual deficit (Orphanet:1065)
Argininemia (Orphanet:90)
Aspartylglucosaminuria (Orphanet:93)
Ataxia - pancytopenia (Orphanet:2585)
Ataxia with vitamin E deficiency (Orphanet:96)
Ataxia-deafness-retardation syndrome (Orphanet:1188)
Ataxia-telangiectasia (Orphanet:100)
Atypical Rett syndrome (Orphanet:3095)
Autosomal dominant cerebellar ataxia (Orphanet:99)
Autosomal dominant striatal neurodegeneration (Orphanet:228169)
Autosomal recessive cerebelloparenchymal disorder type 3 (Orphanet:1170)
Autosomal recessive spastic paraplegia type 11 (Orphanet:2822)
Bannayan-Riley-Ruvalcaba syndrome (Orphanet:109)
Baraitser-Winter syndrome (Orphanet:2995)
Bardet-Biedl syndrome (Orphanet:110)
Bardet-Biedl syndrome 2 (OMIM:615981)
Bardet-Biedl syndrome 4 (OMIM:615982)
Bardet-Biedl syndrome 7 (OMIM:615984)
Bardet-Biedl syndrome 9 (OMIM:615986)
Beckwith-Wiedemann syndrome (Orphanet:116)
Benign familial infantile seizures (Orphanet:306)
Beta-mannosidosis (Orphanet:118)
Beta-ureidopropionase deficiency (Orphanet:65287)
Blepharophimosis-intellectual deficit syndrome, Ohdo type (Orphanet:2728)
Botulism (Orphanet:1267)
Branchio-oculo-facial syndrome (Orphanet:1297)
CADASIL (Orphanet:136)
CAMOS syndrome (Orphanet:83472)
CHARGE syndrome (Orphanet:138)
Cabezas syndrome (Orphanet:85293)
Camurati-Engelmann disease (Orphanet:1328)
Cardiofaciocutaneous syndrome (Orphanet:1340)
Carnitine palmitoyl transferase 1A deficiency (Orphanet:156)
Cataract - deafness - hypogonadism (Orphanet:1383)
Central bilateral macrogyria (Orphanet:2431)
Central congenital hypothyroidism (Orphanet:226298)
Cerebellar ataxia - ectodermal dysplasia (Orphanet:1174)
Cerebellar ataxia - hypogonadism (Orphanet:1173)
Cerebro-reno-digital syndrome (Orphanet:1396)
Cerebroretinal vasculopathy (Orphanet:3421)
Cerebrotendinous xanthomatosis (Orphanet:909)
Choreoacanthocytosis (Orphanet:2388)
Christianson syndrome (Orphanet:85278)
Classic galactosemia (Orphanet:79239)
Coffin-Lowry syndrome (Orphanet:192)
Cogan syndrome (Orphanet:1467)
Cohen syndrome (Orphanet:193)
Congenital rubella syndrome (Orphanet:290)
Cornelia de Lange syndrome (Orphanet:199)
Craniolenticulosutural dysplasia (Orphanet:50814)
Cystinosis (Orphanet:213)
Deafness - small bowel diverticulosis - neuropathy (Orphanet:3217)
Deafness - epiphyseal dysplasia - short stature (Orphanet:3218)
Deafness - genital anomalies - metacarpal and metatarsal synostosis (Orphanet:3224)
Deafness - lymphedema - leukemia (Orphanet:3226)
Delayed speech - facial asymmetry - strabismus - ear lobe creases (Orphanet:3038)
Dermatomyositis (Orphanet:221)
Distal 22q11.2 microdeletion syndrome (Orphanet:261330)
Distal 22q11.2 microduplication syndrome (Orphanet:261337)
Distal 7q11.23 microduplication syndrome (Orphanet:261102)
Dwarfism - intellectual deficit - eye abnormality (Orphanet:2650)
Dyggve-Melchior-Clausen disease (Orphanet:239)
Early-onset parkinsonism - intellectual deficit (Orphanet:2379)
Ectodermal dysplasia - blindness (Orphanet:1806)
Ehlers-Danlos syndrome, arthrochalasic type (Orphanet:1899)
Ehlers-Danlos syndrome, dermatosparaxis type (Orphanet:1901)
Encephalocraniocutaneous lipomatosis (Orphanet:2396)
Epidermolysis bullosa simplex with muscular dystrophy (Orphanet:257)
Erdheim-Chester disease (Orphanet:35687)
Erythrokeratodermia - ataxia (Orphanet:1955)
Facial dysmorphism - shawl scrotum - joint laxity (Orphanet:1778)
Familial developmental dysphasia (Orphanet:1799)
Familial or sporadic hemiplegic migraine (Orphanet:569)
Familial thrombocytosis (Orphanet:71493)
Filippi syndrome (Orphanet:3255)
Floating-Harbor syndrome (Orphanet:2044)
Flynn-Aird syndrome (Orphanet:2047)
Foodborne botulism (Orphanet:228371)
Fountain syndrome (Orphanet:3219)
Fragile X syndrome (Orphanet:908)
Fragile X-associated tremor/ataxia syndrome (Orphanet:93256)
Free sialic acid storage disease (Orphanet:834)
Freeman-Sheldon syndrome (Orphanet:2053)
Fried syndrome (Orphanet:85335)
Fumaric aciduria (Orphanet:24)
Galactosemia (Orphanet:352)
Gaucher disease type 3 (Orphanet:77261)
Genitopatellar syndrome (Orphanet:85201)
German syndrome (Orphanet:2077)
Ghosal hematodiaphyseal dysplasia (Orphanet:1802)
Glutaryl-CoA dehydrogenase deficiency (Orphanet:25)
Glycogen storage disease due to acid maltase deficiency (Orphanet:365)
Goldenhar syndrome (Orphanet:374)
Good syndrome (Orphanet:169105)
HERNS syndrome (Orphanet:63261)
Hall-Riggs syndrome (Orphanet:2107)
Hashimoto-Pritzker syndrome (Orphanet:99872)
Hereditary continuous muscle fiber activity (Orphanet:972)
Hereditary myoclonus - progressive distal muscular atrophy (Orphanet:2590)
Hereditary vascular retinopathy (Orphanet:71291)
Histidinemia (Orphanet:2157)
Huntington disease-like 3 (Orphanet:157946)
Hypertrichosis cubiti - short stature (Orphanet:2220)
Hypertryptophanemia (Orphanet:2224)
Hypoglossia - hypodactyly (Orphanet:989)
Ichthyosis - alopecia - eclabion - ectropion - intellectual deficit (Orphanet:2269)
Ichthyosis - hepatosplenomegaly - cerebellar degeneration (Orphanet:2274)
Infant botulism (Orphanet:178478)
Infantile axonal neuropathy (Orphanet:2679)
Infantile-onset ascending hereditary spastic paralysis (Orphanet:293168)
Intellectual deficit - balding - patella luxation - acromicria (Orphanet:3041)
Intellectual deficit - sparse hair - brachydactyly (Orphanet:3051)
Intellectual deficit, Buenos-Aires type (Orphanet:3079)
Intellectual deficit, X-linked - dysmorphism - cerebral atrophy (Orphanet:2958)
Intellectual deficit, X-linked - seizures - psoriasis (Orphanet:3052)
Intellectual deficit, X-linked, Cantagrel type (Orphanet:85277)
Intellectual deficit, X-linked, Pai type (Orphanet:85322)
Intellectual deficit, X-linked, Shashi type (Orphanet:85286)
Intellectual deficit, X-linked, Vitale type (Orphanet:85289)
Intellectual deficit, X-linked, Wittwer type (Orphanet:85291)
Intellectual disability-developmental delay-contractures syndrome (Orphanet:3454)
Intestinal botulism (Orphanet:178481)
Isolated cerebellar hypoplasia/agenesis (Orphanet:1398)
Isolated glycerol kinase deficiency (Orphanet:408)
Juvenile amyotrophic lateral sclerosis (Orphanet:300605)
Juvenile dermatomyositis (Orphanet:93672)
Juvenile primary lateral sclerosis (Orphanet:247604)
Kallmann syndrome (Orphanet:478)
Kennedy disease (Orphanet:481)
Kleefstra syndrome (Orphanet:261494)
Kleefstra syndrome due to 9q34 microdeletion (Orphanet:96147)
Koolen-De Vries syndrome (Orphanet:96169)
L-2-hydroxyglutaric aciduria (Orphanet:79314)
L1 syndrome (Orphanet:275543)
Locked-in syndrome (Orphanet:2406)
Low birth weight - dwarfism - dysgammaglobulinemia (Orphanet:2621)
MASA syndrome (Orphanet:2466)
MELAS (Orphanet:550)
Mandibulofacial dysostosis-microcephaly syndrome (Orphanet:79113)
Marinesco-Sjögren syndrome (Orphanet:559)
Megalocornea-intellectual deficit syndrome (Orphanet:2479)
Metachromatic leukodystrophy (Orphanet:512)
Microcephaly - cervical spine fusion anomalies (Orphanet:2522)
Microcephaly - deafness - intellectual deficit (Orphanet:2533)
Microduplication Xp11.22-p11.23 syndrome (Orphanet:217377)
Microphthalmia with linear skin defects syndrome (Orphanet:2556)
Microphthalmia, Lenz type (Orphanet:568)
Mietens syndrome (Orphanet:2557)
Mild Canavan disease (Orphanet:314918)
Monosomy 22q13 (Orphanet:48652)
Mucolipidosis type 4 (Orphanet:578)
Muscle-eye-brain disease (Orphanet:588)
Muscular pseudohypertrophy - hypothyroidism (Orphanet:2349)
Myoclonus - cerebellar ataxia - deafness (Orphanet:2589)
Nager syndrome (Orphanet:245)
Narcolepsy-cataplexy (Orphanet:2073)
Nasu-Hakola disease (Orphanet:2770)
Neuhauser-Eichner-Opitz syndrome (Orphanet:2672)
Neuralgic amyotrophy (Orphanet:2901)
Neurodegeneration with brain iron accumulation (Orphanet:385)
Neuroferritinopathy (Orphanet:157846)
Neurofibromatosis type 1 (Orphanet:636)
Neurofibromatosis type 2 (Orphanet:637)
Neuronal ceroid lipofuscinosis (Orphanet:216)
Neuronal intranuclear inclusion disease (Orphanet:2289)
Niemann-Pick disease type C (Orphanet:646)
Non-polyposis Turcot syndrome (Orphanet:99817)
Noonan syndrome (Orphanet:648)
Oculocerebrocutaneous syndrome (Orphanet:1647)
Oculocerebrorenal syndrome (Orphanet:534)
Oculodentodigital dysplasia (Orphanet:2710)
Olivopontocerebellar atrophy - deafness (Orphanet:2732)
Osteopathia striata - cranial sclerosis (Orphanet:2780)
Otofaciocervical syndrome (Orphanet:2792)
Pantothenate kinase-associated neurodegeneration (Orphanet:157850)
Paraplegia - brachydactyly - cone-shaped epiphysis (Orphanet:2823)
Pelizaeus-Merzbacher disease (Orphanet:702)
Pellagra-like skin rash-neurological manifestations (Orphanet:2837)
Pendred syndrome (Orphanet:705)
Peroxisomal acyl-CoA oxidase deficiency (Orphanet:2971)
Phosphoribosylpyrophosphate synthetase superactivity (Orphanet:3222)
Pitt-Hopkins syndrome (Orphanet:2896)
Polymyositis (Orphanet:732)
Posterior cortical atrophy (Orphanet:54247)
Proximal 16p11.2 microdeletion syndrome (Orphanet:261197)
Pseudoprogeria syndrome (Orphanet:2985)
Psychogenic movement disorders (Orphanet:71519)
Pyridoxine-dependent epilepsy (Orphanet:3006)
Pyruvate dehydrogenase deficiency (Orphanet:765)
Radio-ulnar synostosis - intellectual deficit - hypotonia (Orphanet:3270)
Recessive X-linked ichthyosis (Orphanet:461)
Refsum disease (Orphanet:773)
Retinal vasculopathy and cerebral leukodystrophy (Orphanet:247691)
Rett syndrome (Orphanet:778)
Rheumatic fever (Orphanet:3099)
Riboflavin transporter deficiency (Orphanet:97229)
SHORT syndrome (Orphanet:3163)
Schilbach-Rott syndrome (Orphanet:2353)
Schwartz-Jampel syndrome (Orphanet:800)
Sialidosis type 1 (Orphanet:812)
Sialidosis type 2 (Orphanet:87876)
Simpson-Golabi-Behmel syndrome (Orphanet:373)
Sjögren-Larsson syndrome (Orphanet:816)
Smith-Magenis syndrome (Orphanet:819)
Sneddon syndrome (Orphanet:820)
Spastic ataxia with congenital miosis (Orphanet:1182)
Spastic paraplegia - facial-cutaneous lesions (Orphanet:2819)
Spastic paraplegia - nephritis - deafness (Orphanet:2820)
Spastic paraplegia - precocious puberty (Orphanet:2826)
Spastic paraplegia type 2 (Orphanet:99015)
Spondylometaphyseal dysplasia, Golden type (Orphanet:168544)
Stormorken-Sjaastad-Langslet syndrome (Orphanet:3204)
Sturge-Weber syndrome (Orphanet:3205)
Syndromic X-linked ichthyosis (Orphanet:281090)
Syndromic X-linked intellectual deficit 7 (Orphanet:85274)
Syndromic X-linked intellectual deficit due to JARID1C mutation (Orphanet:85279)
Takayasu arteritis (Orphanet:3287)
Thumb deformity - alopecia - pigmentation anomaly (Orphanet:2251)
Thymic tumor (Orphanet:100100)
Toluene embryopathy (Orphanet:1920)
Treacher-Collins syndrome (Orphanet:861)
Trisomy 13 (Orphanet:3378)
Trisomy 20p (Orphanet:261318)
Trisomy Xq28 (Orphanet:1762)
Tyrosinemia type 2 (Orphanet:28378)
Vitamin B12-unresponsive methylmalonic acidemia (Orphanet:27)
Vitamin B12-unresponsive methylmalonic acidemia type mut- (Orphanet:79312)
Von Hippel-Lindau disease (Orphanet:892)
Weaver-Williams syndrome (Orphanet:3448)
Williams syndrome (Orphanet:904)
Wilson-Turner syndrome (Orphanet:3459)
Wolfram syndrome (Orphanet:3463)
Woolly hair - hypotrichosis - everted lower lip - outstanding ears (Orphanet:1409)
Worster-Drought syndrome (Orphanet:3465)
Wound botulism (Orphanet:178475)
Wyburn-Mason syndrome (Orphanet:53719)
X-linked Charcot-Marie-Tooth disease type 1 (Orphanet:101075)
X-linked Charcot-Marie-Tooth disease type 2 (Orphanet:101076)
X-linked Charcot-Marie-Tooth disease type 3 (Orphanet:101077)
X-linked Charcot-Marie-Tooth disease type 4 (Orphanet:101078)
X-linked Charcot-Marie-Tooth disease type 5 (Orphanet:99014)
X-linked creatine transporter deficiency (Orphanet:52503)
X-linked intellectual deficit - cerebellar hypoplasia (Orphanet:137831)
X-linked intellectual deficit - hypotonic face (Orphanet:73220)
X-linked intellectual deficit with marfanoid habitus (Orphanet:776)
X-linked intellectual deficit, Najm type (Orphanet:163937)
X-linked sideroblastic anemia - ataxia (Orphanet:2802)
Zimmermann-Laband syndrome (Orphanet:3473)
Zlotogora-Ogur syndrome (Orphanet:3253)