Atrial fibrillation, familial, 17

General Information (adopted from Orphanet):

Synonyms, Signs: ATFB17
familial atrial fibrillation, 17
Long QT syndrome 10
Number of Symptoms 0
OMIM Id: 611819

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant
23604097 [IBIS]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: Familial atrial fibrillation
 -Rare cardiac disease
 -Rare genetic disease


Atrial fibrillation (AF) is the most prevalent type of cardiac arrhythmia and is commonly associated with other cardiovascular disorders, but in up to 30% of cases there is no evidence of overt heart disease. This condition is called lone or idiopathic AF. About 15% of lone AF presents as familial disorder. (PMID:24333117, 23551519). ATFB17 is a sub-type of familial atrial fibrillation and is characterized by mutations (p.V162G, p.I166L) in the SCN4B gene (PMID:23604097). SCN4B is also associated with familial long QT syndrome 10, a sub-type of the Romano-Ward syndrome (PMID:17592081) or sudden infant death (PMID:20226894). This indicates that AF may share a common genetic origin with long QT syndrome as well as sudden infant death. For symptom annotation please refer to familial atrial fibrillation.

Symptom Information: Sort by abundance 

Associated genes:


ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference
SCN4B rs587777559 pathogenic RCV000128816.2
SCN4B rs587777560 pathogenic RCV000128817.2

Additional Information: