Ventricular fibrillation, paroxysmal familial, 2

General Information (adopted from Orphanet):

Synonyms, Signs: VF2
Number of Symptoms 0
OMIM Id: 612956

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant
19285295 [IBIS]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: Idiopathic ventricular fibrillation, not Brugada type
 -Rare cardiac disease
 -Rare genetic disease


VF2 is a sub-type idiopathic ventricular fibrillation, not Brugada type (Phenodis:2422). For symptom annotation please refer to idiopathic ventricular fibrillation, not Brugada type.

Symptom Information: Sort by abundance 

Associated genes:


ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference
DPP6 rs606231226 pathogenic RCV000018285.29

Additional Information:

Clinical Description OMIM Alders et al. (2009) studied 4 families segregating idiopathic ventricular fibrillation (IVF) who came from the same area in the Netherlands and were genealogically linked through multiple lines. The proband in the first family came to medical attention ...
Molecular genetics OMIM Alders et al. (2009) considered the DPP6 gene to be an excellent candidate for ventricular fibrillation in the Dutch families because it encodes a putative component of the transient outward current in the heart (Radicke et al., 2005). ...