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(chrI - chrXVI,chrMito,2-micron)

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MPact protein interaction

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WUBLAST DNA/Protein

About CYGD


MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
ACT1 Actin 
Entry:YFL039c
Alias:ABY1; END7; (SLC1)
Classification:known protein | 5422 Entries
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (44.8 %) ;  |  Homologs in   Hemiascomycota (100 %);  Basidiomycota (89.9 %);  Fungi (100 %);  Eukaryota (100 %);  Plants (86.2 %);  Mammalia (89.1 %);  Human (89.1 %);  Bacteria (20.8 %);  All except yeast (100 %)

  • strong similarity to actin of other yeasts and mammalian actin
Functional Classification:
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transport routes
    ....cytoskeleton-dependent transport
    ......actin dependent transport | 1 Entry | Evi | PUBMED
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transport routes
    ....cellular export and secretion
    ......vesicular cellular export
    ........exocytosis | 33 Entries | Evi | PUBMED
  • CELL RESCUE, DEFENSE AND VIRULENCE
    ..stress response
    ....osmotic and salt stress response | 59 Entries | Evi | PUBMED
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transport routes
    ....cellular import
    ......vesicular cellular import
    ........endocytosis | 59 Entries | Evi | PUBMED
  • CELL TYPE DIFFERENTIATION
    ..fungal/microorganismic cell type differentiation
    ....fungal and other eukaryotic cell type differentiation
    ......development of asco- basidio- or zygospore | 167 Entries | Evi
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transport routes
    ....vesicular transport (Golgi network, etc.) | 200 Entries | Evi | PUBMED
  • CELL TYPE DIFFERENTIATION
    ..fungal/microorganismic cell type differentiation
    ....fungal and other eukaryotic cell type differentiation
    ......budding, cell polarity and filament formation | 313 Entries | Evi | PUBMED
  • PROTEIN FATE (folding, modification, destination)
    ..protein modification
    ....modification by acetylation, deacetylation | 69 Entries | Evi | PUBMED
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....mitotic cell cycle and cell cycle control | 447 Entries | Evi
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....cytokinesis (cell division) /septum formation and hydrolysis | 71 Entries | Evi | PUBMED
  • PROTEIN FATE (folding, modification, destination)
    ..protein targeting, sorting and translocation | 280 Entries | Evi
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....cell cycle dependent cytoskeleton reorganization
    ......spindle pole body/centrosome and microtubule cycle | 42 Entries | Evi | PUBMED
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....cell cycle dependent cytoskeleton reorganization
    ......cell cycle dependent actin filament reorganization | 7 Entries | Evi | PUBMED
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transported compounds (substrates)
    ....protein transport | 140 Entries | Evi
InterPro:
Localization:  ACT1 localization details
  • cytoskeleton
  • cytoskeleton
    ..actin cytoskeleton
Remarks:
    • polymerization properties are similar to vertebrate actin
    • actin filaments are not known to depolymerize in yeast
    • not subjected to unusual N-terminal processing as occurs for mammalian actin
    • actin cables disappear rapidly after increase of osmolarity
    • unpolymerized actin pool is very small in yeast
Phenotypes:  Disruption: ACT1 details
  • lethal
___
  • act1-1 is osmosensitive and ts
  • act1-3 and act1-133 mutations affect mitochondrial mobility and fusion during meiosis
  • act1-3 at non-permissive temperature results in large spherical mitochondria
  • diploid cells with a single ACT1 gene do not grow in high osmolarity media
  • act1-1 and act1-2 have cortical actin patches distributed evenly over mother and daughter cells at all stages of cell cycle
  • act1 mutants are defective in the bipolar budding pattern
  • vacuole inheritance is defective in a variety of actin mutants
___
  • Conditional phenotypes
    ..Heat-sensitivity (ts) | 313 Entries
  • Cell morphology and organelle mutants
    ..Budding mutants
    ....Bud localization | 35 Entries
  • Cell morphology and organelle mutants
    ..Cell wall mutants
    ....Osmotic sensitivity (Osm) | 43 Entries
  • Cell morphology and organelle mutants
    ..Cytoskeleton mutants
    ....Actin cytoskeleton mutants | 48 Entries
  • Cell morphology and organelle mutants
    ..Mitochondrial mutants | 37 Entries
  • Cell morphology and organelle mutants
    ..Vacuolar mutants
    ....other vacuolar mutants | 49 Entries
Overexpression:
  • overproduction is lethal
Click for larger Map
Physical Features
Coordinates:54695 - 53260 (C)
Length:1436 nt
Contig:chrVI
Exon Coordinates:54695 - 54686 | Evi | PUBMED
54377 - 53260 | Evi | PUBMED
GC Content:43.8 %
Protein Length:375 aa
Isoelectric Point:5.44
Molecular Weight:41689.8 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: L00026
EMBL: V01288
EMBL: V01289
EMBL: V01290
EMBL: D50617
EMBL: D44598
PIR: A03005
UniProtKB: P60010
NCBI: NP_116614
Additional Links:
CYGD Pathways:
  • Interactions between constituents of the 12S complex and signalling components
  • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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