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About CYGD


MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
ICL1 Isocitrate lyase 
Entry:YER065c
Classification:known protein | 5422 Entries
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (39.9 %) ;  |  Homologs in   Hemiascomycota (98.4 %);  Basidiomycota (55 %);  Fungi (98.4 %);  Eukaryota (98.4 %);  Plants (51.3 %);  Mammalia (11.9 %);  Human (11.9 %);  Bacteria (32.6 %);  All except yeast (98.4 %)

  • strong similarity to isocitrate lyases of other fungi and Icl2p
Functional Classification:
EC Number:
  • 4.1.3.1: Lyases
    ..Carbon-Carbon Lyases
    ....Oxo-Acid-Lyases
    ......isocitrate lyase | 1 Entry | Evi | PUBMED
Pathway:
  • gluconeogenesis
  • glyoxylate cycle
InterPro:
Localization:  ICL1 localization details
  • cytoplasm
Remarks:
  • may be inactivated by phosphorylation under glucose conditions | PUBMED
  • protein purification | PUBMED
  • lys-216 is not essential for function
  • decapeptide KTKRNYSARD located between amino acid 37 and 46 is important for glucose induced proteolytic inactivation
Phenotypes:  Disruption: ICL1 details
  • viable
___
  • icl deletion mutants are unable to grow on ethanol | PUBMED
  • icl1 mutants do not grow on C2 carbon sources, but do grow on C3 carbon sources | PUBMED
___
  • Auxotrophies, carbon and nitrogen utilization defects
    ..Carbon utilization
    ....other carbon utilization defects | 27 Entries
Click for larger Map
Physical Features
Coordinates:286912 - 285239 (C)
Length:1674 nt
Contig:chrV
Exon Coordinates:286912 - 285239
GC Content:44 %
Protein Length:557 aa
Isoelectric Point:5.98
Molecular Weight:62408.9 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: X61271
EMBL: X65554
EMBL: U18813
PIR: S22386
UniProtKB: P28240
NCBI: NP_010987
Additional Links:
CYGD Pathways:
  • Metabolic and genetic control of gene expression
  • The role of MIG1 in metabolic functions
  • CYGD Tables:
  • Impact of Mig1p upon the expression of other genes
  • Putative targets of the GCN4 transcription factor
  • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

  • To submit new information about this entry, please write to

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