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| Search ORF/Gene/Description |
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Chromosome
(chrI - chrXVI,chrMito,2-micron) |
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| Entry: | YER016w | | Alias: | YEB1 | | Classification: | known protein | 5422 Entries | Evi
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PUBMED
| | Feature Type: | CDS | | Features |  |
Blast-Simap
DNA VIEW
PROTEIN VIEW
| | Similarity: |
similarity to human EB1 and t-Cell activation protein and mouse APC-binding protein EB1 |
PUBMED
| | Functional Classification: | - BIOGENESIS OF CELLULAR COMPONENTS
..cytoskeleton/structural proteins
....microtubule cytoskeleton
| 47 Entries | Evi
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PUBMED
- CELL CYCLE AND DNA PROCESSING
..cell cycle
....mitotic cell cycle and cell cycle control
......cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle)
| 67 Entries | Evi
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PUBMED
- CELL CYCLE AND DNA PROCESSING
..cell cycle
....nuclear and chromosomal cycle
......nuclear migration
| 15 Entries | Evi
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PUBMED
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InterPro:
| | | Localization: | BIM1 localization detailscytoplasmcytoskeletoncytoskeleton
..tubulin cytoskeleton | | Remarks: | the human EB1 protein interacts with the human ABC protein, which is implicated in sporadic and familial forms of colorectal cancer, see |
PUBMED
| | Phenotypes: | Disruption: BIM1 details___
deletion of BIM1 results in a strong bilateral karyogamy defect, hypersensitivity to benomyl, and aberrant spindle behavior, all phenotypes associated with mutations affecting microtubules in yeast, and inviability at extreme temperatures (i.e., gt=370C or lt=140C) |
PUBMED
mutants do proceed to cytokinesis even if daughter cells do not contain a nucleus |
PUBMED
null mutants grow poorly at 15C |
PUBMED
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Conditional phenotypes
..Heat-sensitivity (ts) | 313 Entries Conditional phenotypes
..Cold-sensitivity (cs) | 105 Entries Conditional phenotypes
..Slow-growth (slg) | 237 Entries Cell cycle defects
..other cell cycle defects | 207 Entries Cell morphology and organelle mutants
..Cytoskeleton mutants
....Tubulin cytoskeleton mutants
......benomyl sensitivity | 33 Entries | | Overexpression: | overexpression of BIM1 in wild-type cells is lethal resulting in cell cycle arrest with large budded cells |
PUBMED
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