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Chromosome
(chrI - chrXVI,chrMito,2-micron)

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  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
PER1 Protein involved in manganese homeostasis 
Entry:YCR044c
Alias:COS16
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (10.8 %) ;  |  Homologs in   Hemiascomycota (91.6 %);  Basidiomycota (33.4 %);  Fungi (91.6 %);  Eukaryota (91.6 %);  Plants (30.9 %);  Mammalia (29.5 %);  Human (27.1 %);  Bacteria (15 %);  All except yeast (91.6 %)
  • weak similarity to mouse taurine and beta-alanine transporter
  • strong similarity to SPAC823.07 S. pombe
Functional Classification:
  • INTERACTION WITH THE ENVIRONMENT
    ..homeostasis
    ....homeostasis of cations
    ......homeostasis of metal ions (Na, K, Ca etc.) | 98 Entries | Evi | PUBMED
  • CELL RESCUE, DEFENSE AND VIRULENCE
    ..stress response
    ....unfolded protein response (e.g. ER quality control) | 69 Entries | Evi | PUBMED
TC Class:
  • The unclassifiable, putative or spurios Transporters
    ..The Putative Uncharacterized Transporters
    ....The Singletons
    ......The Singletons, nuclear DNA | 105 Entries | Evi | PUBMED
InterPro:
Localization:  PER1 localization details
  • ER
  • vacuole
  • vacuole
    ..vacuolar membrane
 TargetP: Secretory pathway  (RC = 1)
Remarks:
  • belongs to the group II COS genes | PUBMED
    Phenotypes:  Disruption: PER1 details
    • viable
    ___
    • mutants are sensitive to MgCl2 | PUBMED
    • mutants do not sporulate | PUBMED
    • mutants do show slight growth defect at 36C | PUBMED
    • group II COS mutants do not secrete CPY | PUBMED
    • deletion mutant exacerbated the Mn2+ sensitivity of PMR1 mutants | PUBMED
    • cos16 deletion mutant suppresses the sensitivity of a pmr1 deletion mutant, a smf1 deletion mutant and a cdc1-1ts mutant | PUBMED
    ___
    • Conditional phenotypes
      ..Heat-sensitivity (ts) | 313 Entries
    • Mating and sporulation defects
      ..Sporulation efficiency | 112 Entries
    • Cell morphology and organelle mutants
      ..Secretory mutants | 61 Entries
    • Stress response defects
      ..Divalent cations and heavy metals
      ....Divalent cations and heavy metals sensitivity | 68 Entries
    Click for larger Map
    Physical Features
    Coordinates:207946 - 206873 (C)
    Length:1074 nt
    Contig:chrIII
    Exon Coordinates:207946 - 206873
    GC Content:40.8 %
    Protein Length:357 aa
    Isoelectric Point:6.41
    Molecular Weight:42541.8 Da
    Transmembrane Domains:Begin - End / Length (aa)
    155 - 177 / 23
    187 - 204 / 18
    211 - 233 / 23
    248 - 270 / 23
    291 - 313 / 23
    323 - 345 / 23
    6 TM- Domains
    Retrieve Sequence: DNA /Protein
    Literature | References
    CYGD curated Lit.:PubMed
    PubMed:Search abstracts
    PubMed Central:Search full-text articles
    Sequence References:
    EMBL: X59720
    PIR: S19457
    UniProtKB: P25625
    NCBI: NP_009973
    Additional Links:
    LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
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