| Entry: | YBL005w |
| Alias: | AMY2; PDR7; TPE3; YBL0323; (PDR4) |
| Classification: | known protein | 5422 Entries | Evi
|
PUBMED
|
| Feature Type: | CDS |
| Features |
 |
Blast-Simap
DNA VIEW
PROTEIN VIEW
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| Similarity: |
strong similarity to Pdr1pmember of the binuclear zinc cluster protein family |
| Functional Classification: | - CELL RESCUE, DEFENSE AND VIRULENCE
..disease, virulence and defense
....resistance proteins
......chemical agent resistance
| 29 Entries | Evi
|
PUBMED
- CELL RESCUE, DEFENSE AND VIRULENCE
..detoxification
| 117 Entries | Evi
- TRANSCRIPTION
..RNA synthesis
....mRNA synthesis
......transcriptional control
........transcription activation
| 42 Entries | Evi
|
PUBMED
- PROTEIN WITH BINDING FUNCTION OR COFACTOR REQUIREMENT (structural or catalytic)
..nucleic acid binding
....DNA binding
| 159 Entries | Evi
|
PUBMED
|
|
InterPro:
| |
| Localization: | PDR3 localization details |
| Remarks: | binds to DNA at reverted repeat or inverted palindrome (CCGCGG)can be activated by Pdr1pautoactivation is involved in the drug resistance phenomenoncan be mutated to confer multidrug resistance fos/jun DNA-binding homology domainpredicted GAL4-like DNA-binding domain |
| Phenotypes: | Disruption: PDR3 details___
PDR3 dominant mutations cause overexpression of PDR5 and resistance to cycloheximide and oligomycinpdr3-33 mutation leads to resistance to the drug diazaborine |
PUBMED
___
Sensitivity to aminoacid analogs and other drugs
..Cycloheximide
....Cycloheximide resistance | 7 Entries Sensitivity to aminoacid analogs and other drugs
..Oligomycin
....Oligomycin resistance | 3 Entries Sensitivity to aminoacid analogs and other drugs
..Diazaborine
....Diazaborine resistance | 3 Entries |
| Overexpression: | overexpression causes increases resistance to oligomycin and cycloheximideresistance to oligomycin in overexpressing strain is not dependent on Pdr5p |
| Suppression: | PDR3 and PDR1 cross-complement pdr1 or pdr3 mutants |
