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MPact protein interaction

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About CYGD

MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
KRE6 Glucan synthase subunit 
Alias:CWH48; P9584.2
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Paralogs (67.2 %) ;  |  Homologs in   Hemiascomycota (96.8 %);  Basidiomycota (39.2 %);  Fungi (96.8 %);  Eukaryota (96.8 %);  Plants (9.8 %);  Mammalia (8.9 %);  Human (9.6 %);  Bacteria (12.9 %);  All except yeast (96.8 %)

  • strong similarity to Skn1p
  • 66% identical to Skn1p
Functional Classification:
    ..C-compound and carbohydrate metabolism
    ....sugar, glucoside, polyol and carboxylate metabolism
    ......sugar, glucoside, polyol and carboxylate catabolism | 79 Entries | Evi | PUBMED
Localization:  KRE6 localization details
  • cytoplasm
  • golgi
  • vacuole
  • phosphorylation probably occurs on large amino-terminal cytoplasmic domain and may be regulatory
  • phosphorylation level not detectably altered in pkc1 mutant
  • type II transmembrane protein
Phenotypes:  Disruption: KRE6 details
  • viable
  • mutants are resistant to k1 killer toxin | PUBMED
  • null mutant has 50% reduced level of cell wall beta-1,6-glucan | PUBMED
  • null mutant has slow growth | PUBMED
  • mutations may cause flocculation | PUBMED
  • mutants are also affected in beta-1,3-glucan synthesis
  • mutants are calcofluor white hypersensitive | PUBMED
  • mutants are zymolyase hypersensitive | PUBMED
  • mutants show increased ratio of mannose to glucose in the cell wall | PUBMED
  • Cell morphology and organelle mutants
    ..Cell wall mutants
    ....Calcofluor white
    ......Calcofluor white sensitivity | 88 Entries
  • Cell morphology and organelle mutants
    ..Cell wall mutants
    ....Killer toxin
    ......Killer toxin resistance | 21 Entries
  • Cell morphology and organelle mutants
    ..Cell wall mutants
    ....other cell wall mutants | 73 Entries
  • overproduction does not rescue mpk1 or mkk1 mkk2 mutants for cell lysis defect
  • slow growth phenotype of null mutant not affected by Pkc1p overproduction
  • slow growth and killer resistance phenotypes are suppressed by Skn1p overproduction
Click for larger Map
Physical Features
Coordinates:857579 - 859741 (W)
Length:2163 nt
Exon Coordinates:857579 - 859741
GC Content:41.3 %
Protein Length:720 aa
Isoelectric Point:4.49
Molecular Weight:80122.9 Da
Transmembrane Domains:Begin - End / Length (aa)
253 - 275 / 23

1 TM- Domain
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: U28371
PIR: S61143
UniProtKB: P32486
NCBI: NP_015485
Additional Links:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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