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(chrI - chrXVI,chrMito,2-micron)

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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
NCE102 Protein involved in non-classical protein export pathway 
Entry:YPR149w
Alias:NCE2; P9659.2; RTG2S2
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (61.5 %) ;  |  Homologs in   Hemiascomycota (99.4 %);  Basidiomycota (9.2 %);  Fungi (99.4 %);  Eukaryota (99.4 %);  Plants (16.9 %);  Mammalia (20.8 %);  Human (20.9 %);  Bacteria (16.8 %);  All except yeast (99.4 %)
  • strong similarity to YGR131w
Functional Classification:
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transport routes
    ....cellular export and secretion | 76 Entries | Evi | PUBMED
  • PROTEIN FATE (folding, modification, destination)
    ..protein targeting, sorting and translocation | 280 Entries | Evi | PUBMED
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transported compounds (substrates)
    ....protein transport | 140 Entries | Evi | PUBMED
TC Class:
  • Non Transporting Mebrane Proteins
    ..Trafficking
    ....SEC
    ......The Non-classical Secretion Subfamily | 2 Entries | Evi | PUBMED
Localization:  NCE102 localization details
  • cytoplasm
  • ER
  • mitochondria
  • punctate composite
 TargetP: Secretory pathway  (RC = 1)
Remarks:
  • Nce2p resembles to bacterial EmrE protein, a antiporter that exchanges protons with toxic cations
    Phenotypes:  Disruption: NCE102 details
    • viable
    ___
    • nce2 disruption mutant is reduced in export of mammalian galectin-1
    • expression of tag-galectin-1 in nce1 mutant strain results in lethality
    • nce2 sec18ts null double mutant total export protein profile is not significant different than the profile from the sec18ts strain
    Suppression:
    • suppressor of mrtg2-5 in the CIT2 retrograde pathway
    Click for larger Map
    Physical Features
    Coordinates:829914 - 830435 (W)
    Length:522 nt
    Contig:chrXVI
    Exon Coordinates:829914 - 830435
    GC Content:42.3 %
    Protein Length:173 aa
    Isoelectric Point:9.55
    Molecular Weight:18967.2 Da
    Transmembrane Domains:Begin - End / Length (aa)
    10 - 28 / 19
    40 - 62 / 23
    72 - 94 / 23
    124 - 146 / 23
    4 TM- Domains
    Retrieve Sequence: DNA /Protein
    Literature | References
    CYGD curated Lit.:PubMed
    PubMed:Search abstracts
    PubMed Central:Search full-text articles
    Sequence References:
    EMBL: U41659
    EMBL: U40829
    EMBL: X71621
    PIR: S69036
    UniProtKB: Q12207
    NCBI: NP_015475
    Additional Links:
    LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
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