| Entry: | YPR032w |
| Alias: | OSG4; SNI1; SOP1; YP9367.12 |
| Classification: | known protein | 5422 Entries | Evi
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PUBMED
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| Feature Type: | CDS |
| Features |
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Blast-Simap
DNA VIEW
PROTEIN VIEW
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| Similarity: |
strong similarity to SRO77 (YBL106c)similarity to Drosophila tumor suppressor gene lethal (2) giant larvae l(2)gl and its human counterpart LLGL |
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| Functional Classification: | - CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
..transport routes
....cellular export and secretion
......vesicular cellular export
........exocytosis
| 33 Entries | Evi
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PUBMED
- CELL TYPE DIFFERENTIATION
..fungal/microorganismic cell type differentiation
....fungal and other eukaryotic cell type differentiation
......budding, cell polarity and filament formation
| 313 Entries | Evi
- CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
..transport routes
....vesicular transport (Golgi network, etc.)
| 200 Entries | Evi
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PUBMED
- BIOGENESIS OF CELLULAR COMPONENTS
..cytoskeleton/structural proteins
| 252 Entries | Evi
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InterPro:
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| Localization: | SRO7 localization detailsbudcell peripheryplasma membranecytoplasm |
| Remarks: | contains domains homologous to the Drosophila tumor suppressor gene lethal (2) giant larvae l(2)gl |
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| Phenotypes: | Disruption: SRO7 details___
sro7 deletion mutant shows no growth defect at 15-37C |
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sro7 sro77 double deletion mutant shows a cold sensitive phenotype |
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sro7 sro77 double deletion mutant shows dispersed actin patches and only short actin cables |
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sro7 sro77 double deletion mutant are hypersensitive to lantriculin |
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sro7 sro77 myo1 triple deletion mutant show abnormal morphology: a filamentous shape between mother and daughter cells |
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sni1 sni2 double mutant has exocytic defect, accumulating post-Golgi vesiclessop1 deletion confers sensitivity to NaCl |
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Exhibits sensitivity at 5 generations when grown in 1 M NaCl. | Evi
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Exhibits sensitivity at 20 generations when grown in 1 M NaCl. | Evi
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PUBMED
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| Overexpression: | multicopy suppressor of myo2 deletion mutant |
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| Suppression: | acts as a multicopy suppressor of rho3 |
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loss of sro7 and sro77 suppresses the colony formation defect, cell seperation defect, and slow growth phenotype of a myo1 deletion mutant |
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a sro7 sro77 double deletion mutant can be complemented by LLGL, the human counterpart of l(2)gl |
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myo1 disruption suppresses the cs phenotype of a sro7 sro77 double deletion mutant |
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MYO2 overexpression suppresses the cs phenotype of a sro7 sro77 double deletion mutant |
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