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Chromosome
(chrI - chrXVI,chrMito,2-micron)

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  I  II  III  IV  V  VI  VII
  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
BFR1 Maintenance of normal ploidy 
Entry:YOR198c
Alias:O4817
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (17.6 %) ;  |  Homologs in   Hemiascomycota (98.1 %);  Basidiomycota (23.7 %);  Fungi (98.1 %);  Eukaryota (98.1 %);  Plants (20.4 %);  Mammalia (11.3 %);  Human (18.8 %);  Bacteria (17.2 %);  All except yeast (98.1 %)
  • similarity to human endosomal protein, and myosin heavy chain proteins
Functional Classification:
  • CELL TYPE DIFFERENTIATION
    ..fungal/microorganismic cell type differentiation
    ....fungal and other eukaryotic cell type differentiation
    ......budding, cell polarity and filament formation | 313 Entries | Evi
  • PROTEIN WITH BINDING FUNCTION OR COFACTOR REQUIREMENT (structural or catalytic)
    ..nucleic acid binding
    ....RNA binding | 190 Entries | Evi | PUBMED
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....mitotic cell cycle and cell cycle control
    ......mitotic cell cycle | 165 Entries | Evi | PUBMED
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....mitotic cell cycle and cell cycle control
    ......cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle) | 67 Entries | Evi | PUBMED
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....cell cycle dependent cytoskeleton reorganization
    ......spindle pole body/centrosome and microtubule cycle | 42 Entries | Evi | PUBMED
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....cytokinesis (cell division) /septum formation and hydrolysis | 71 Entries | Evi | PUBMED
Localization:  BFR1 localization details
  • ER
Remarks:
    • three regions of the protein are predicted to form a coiled-coil
    • it may adopt a rod-shaped rather than a globular configuration
Phenotypes:  Disruption: BFR1 details
  • viable
___
  • null mutant has defects in nuclear segregation and cell morphology
  • a small portion of a bfr1 mutant cell culture increase their ploidy each generation
  • in bfr1 mutant cells maybe anaphase is delayed
___
  • Cell morphology and organelle mutants
    ..other cell morphology mutants | 57 Entries
Suppression:
  • suppress brefeldin A-induced lethality when overexpressed
  • partially suppresses defects of growth and secretion in sec17 when overexpressed
Click for larger Map
Physical Features
Coordinates:720066 - 718654 (C)
Length:1413 nt
Contig:chrXV
Exon Coordinates:720066 - 718654
GC Content:37.7 %
Protein Length:470 aa
Isoelectric Point:9.18
Molecular Weight:54639.6 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: Z75106
EMBL: U06870
PIR: S47887
UniProtKB: P38934
NCBI: NP_014841
Additional Links:
LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
    • To submit new information about this entry, please write to

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