| Entry: | YOR005c |
| Alias: | LIG4; O2525; UND407; UNE452 |
| Classification: | known protein | 5422 Entries |
| Feature Type: | CDS |
| Features |
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Blast-Simap
DNA VIEW
PROTEIN VIEW
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| Similarity: |
similarity to human mRNA for DNA ligase IVsimilarity to ATP-dependent DNA ligasesweak similarity to human FMR1 gene involved in fragile-X syndromehomolog of FMR1 (human) fragile-X syndrome according to Bassett et al. Nature 379, 589 (1996)structural and functional homologue of human DNA ligase IV |
PUBMED
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| Functional Classification: | - CELL TYPE DIFFERENTIATION
..fungal/microorganismic cell type differentiation
....fungal and other eukaryotic cell type differentiation
......development of asco- basidio- or zygospore
| 167 Entries | Evi
- CELL CYCLE AND DNA PROCESSING
..DNA processing
....DNA synthesis and replication
| 138 Entries | Evi
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PUBMED
- CELL CYCLE AND DNA PROCESSING
..DNA processing
....DNA recombination and DNA repair
......DNA repair
| 159 Entries | Evi
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PUBMED
- CELL CYCLE AND DNA PROCESSING
..cell cycle
....meiosis
| 161 Entries | Evi
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| EC Number: | - 6.5.1.1: Ligases
..Forming Phosphoric Ester Bonds
....Forming Phosphoric Ester Bonds
......DNA ligase (ATP)
| 2 Entries | Evi
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PUBMED
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InterPro:
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| Localization: | DNL4 localization details |
| Remarks: | contains two BRCT (BRCA1 C-Terminal) domains at the C-terminus, see |
PUBMED
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| Phenotypes: | Disruption: DNL4 details___
non-homologous end-joining (NHEJ) is impaired in mutants |
PUBMED
rad52 dnl4 double mutants are more sensitive to double-strand breaks than rad52 mutants |
PUBMED
mutants have no cell growth defect |
PUBMED
mutants show normal Cdc9-mediated response to ionizing and UV radiation |
PUBMED
mutants show no defect at 37C in contrast to hdf1 mutants |
PUBMED
homozygous diploid mutants sporulate less efficiently than wild-type cells, and show retarded progression through meiotic prophase I |
PUBMED
homozygous diploid mutants show normal spore viability , but they produce a higher proportion of tetrads with only three viable spores |
PUBMED
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Cell cycle defects
..other cell cycle defects | 207 Entries Mating and sporulation defects
..Sporulation efficiency | 112 Entries |
| Suppression: | mutants are complemented by overexpression of DNL4 but not of CDC9 |
PUBMED
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