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MPact protein interaction

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About CYGD

MIPS Fungal Genomes

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RPP2A Acidic ribosomal protein P2.beta 
Alias:L12EIB; L35; O2060; RPLA2; RPL44; (RPA2); (RPL44)
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Paralogs (61.8 %) ;  |  Homologs in   Hemiascomycota (98.1 %);  Basidiomycota (60.4 %);  Fungi (98.1 %);  Eukaryota (98.1 %);  Plants (56.2 %);  Mammalia (54.8 %);  Human (53 %);  Bacteria (21.7 %);  All except yeast (98.1 %)

  • strong similarity to mammalian acidic ribosomal P2 proteins
Functional Classification:
Localization:  RPP2A localization details
  • cytoplasm
  • phosphorylated by "60S kinase"
  • not assembled onto ribosomes in nucleolus
  • exchanges on and off ribosomes
  • no intron and is present in single copy
  • bilateral hydrophobic zipper that is proposed to play a role in association with other acidic ribosomal proteins
Phenotypes:  Disruption: RPP2A details
  • viable
  • triple or quadruple disruptants of RPP1A RPP1B RPP2A RPP2B are viable but have a cold-sensitive phenotype
  • quadruple disruptants of RPP1A RPP1B RPP2A RPP2B have acidic phosphoprotein-deficient ribosomes
  • quadruple disruptants of RPP1A RPP1B RPP2A RPP2B are unable to sporulate
  • quadruple disruptants of RPP1A RPP1B RPP2A RPP2B have a different 2D gel pattern from wild-type cells with some proteins absent and others more highly expressed
Click for larger Map
Physical Features
Coordinates:254296 - 254616 (W)
Length:321 nt
Exon Coordinates:254296 - 254616
GC Content:47 %
Protein Length:106 aa
Isoelectric Point:3.98
Molecular Weight:10745.8 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: Z74781
EMBL: M26503
EMBL: X06958
PIR: B35109
UniProtKB: P05319
NCBI: NP_014603
Additional Links:
CYGD Tables:
  • S. cerevisiae Cytoplasmic Ribosomal Nomenclature
  • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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