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MPact protein interaction

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About CYGD

MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
POP2 Protein required for glucose derepression 
Alias:CAF1; N3470
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Paralogs (10.2 %) ;  |  Homologs in   Hemiascomycota (95.5 %);  Basidiomycota (23.8 %);  Fungi (95.5 %);  Eukaryota (95.5 %);  Plants (25.8 %);  Mammalia (26.3 %);  Human (24 %);  Bacteria (15.1 %);  All except yeast (95.5 %)

  • similarity to mouse mCAF1 protein and C.elegans cCAF1 protein
Functional Classification:
    ..fungal/microorganismic cell type differentiation
    ....fungal and other eukaryotic cell type differentiation
    ......development of asco- basidio- or zygospore | 167 Entries | Evi
    ..nucleotide/nucleoside/nucleobase metabolism
    ....polynucleotide degradation
    ......RNA degradation | 51 Entries | Evi | PUBMED
    ..C-compound and carbohydrate metabolism
    ....regulation of C-compound and carbohydrate metabolism | 127 Entries | Evi
Localization:  POP2 localization details
  • cytoplasm
  • nucleus
  • mitochondria
  • selected by expression of reporter gene from PGK1 promoter in low glucose
  • CAF1 is a homolog of mCAF1 | PUBMED
  • residues 147 to 171 are necessary for interaction of Pop2p with Dhh1p | PUBMED
  • length of glutamines run may vary
  • polyglutamine stretches residues 81-91, 112-126; glutamine rich region residues 364-371; proline rich region residues 139-155; serine/threonine rich region residues 375-391 | PUBMED
Phenotypes:  Disruption: POP2 details
  • viable
  • mutants do not grow at 15C and 37C on YPD, show reduced growth at 24C and do not grow at 37C on YPG, do not grow at 24C and 37 C on YPG + sorbitol | PUBMED
  • mutants are cold-sensitive at 12 deg | PUBMED
  • mutant shows temperature-sensitive growth | PUBMED
  • mutants are temperature-sensitive at 37 deg on glycerol | PUBMED
  • mutant has staurosporine and caffeine sensitivity | PUBMED
  • mutant shows resistance to glucose derepression | PUBMED
  • mutant shows failure of homozygous diploid cells to sporulate | PUBMED
  • mutant shows reduced amount of reserve carbohydrates | PUBMED
  • mutant fails to fully derepress SUC2 and ICL1 in low glucose
  • mutant has phenotype similar to ccr4 | PUBMED
  • null mutant restore full glucose repression in spt10 or spt6 mutants | PUBMED
  • null mutants fail to grow at 37 deg on rich medium containing glucose | PUBMED
  • null mutants at 37 deg have defective growth in complete medium containing ethanol or glycerol as the sole carbon source
  • mutants are hypersensitive to elevated levels of Li+ ions | PUBMED
  • mutants are partially defective for cell cycle progression at end of mitosis (delayed exit from mitosis) | PUBMED
  • caf1 shows no synthetic lethality with dbf20, sic1 or swi5 in contrast to dbf20 | PUBMED
  • dhh1 delta pop2 delta and dhh1 delta mpt5 delta double mutants are temperature sensitive | PUBMED
  • Conditional phenotypes
    ..Heat-sensitivity (ts) | 313 Entries
  • Conditional phenotypes
    ..Cold-sensitivity (cs) | 105 Entries
  • Mating and sporulation defects
    ..Sporulation efficiency | 112 Entries
  • Auxotrophies, carbon and nitrogen utilization defects
    ..Carbon utilization
    ....Accumulation of storage carbohydrates | 11 Entries
  • Auxotrophies, carbon and nitrogen utilization defects
    ..other auxotrophies, carbon and nitrogen utilization defects | 20 Entries
  • Stress response defects
    ..Divalent cations and heavy metals
    ....Divalent cations and heavy metals sensitivity | 68 Entries
  • Sensitivity to aminoacid analogs and other drugs
    ..Staurosporine sensitivity | 7 Entries
  • staurosporine sensitivity is suppressed by overexpression of Mpt4p | PUBMED
  • mutant suppresses rad52-20 radiation sensitivity | PUBMED
  • overexpression of MPT5 suppresses pop2 sensitivity to caffeine and cell lysis phenotype | PUBMED
Click for larger Map
Physical Features
Coordinates:720649 - 719348 (C)
Length:1302 nt
Exon Coordinates:720649 - 719348
GC Content:44.2 %
Protein Length:433 aa
Isoelectric Point:5.77
Molecular Weight:49682.5 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: Z71667
EMBL: D12808
EMBL: D12807
PIR: S63383
UniProtKB: P39008
NCBI: NP_014450
Additional Links:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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