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Chromosome
(chrI - chrXVI,chrMito,2-micron)

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  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
ARE2 Acyl-CoA sterol acyltransferase 
Entry:YNR019w
Alias:N3206; SAT1
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (47.4 %) ;  |  Homologs in   Hemiascomycota (94.6 %);  Basidiomycota (20.1 %);  Fungi (94.6 %);  Eukaryota (94.6 %);  Plants (22.4 %);  Mammalia (18.8 %);  Human (16.2 %);  Bacteria (14.5 %);  All except yeast (94.6 %)
  • strong similarity to Are1p, similarity to other sterol O-acyltransferases
Functional Classification:
  • CELL TYPE DIFFERENTIATION
    ..fungal/microorganismic cell type differentiation
    ....fungal and other eukaryotic cell type differentiation
    ......development of asco- basidio- or zygospore | 167 Entries | Evi
  • METABOLISM
    ..lipid, fatty acid and isoprenoid metabolism
    ....isoprenoid metabolism
    ......tetracyclic and pentacyclic triterpenes (cholesterin, steroids and hopanoids) metabolism | 36 Entries | Evi | PUBMED
EC Number:
  • 2.3.1.26: Transferases
    ..Acyltransferases
    ....Transferring groups other than amino-acyl groups
    ......sterol O-acyltransferase | 2 Entries | Evi | PUBMED
TC Class:
  • Non Transporting Mebrane Proteins
    ..Lipids
    ....Sterols
    ......The Sterol Acyltransferase Subfamily | 2 Entries | Evi | PUBMED
InterPro:
Localization:  ARE2 localization details
  • integral membrane / endomembranes (not assigned to a specific membrane)
  • ER
Phenotypes:  Disruption: ARE2 details
  • viable
___
  • are2 mutant strain is not reduced in sterol biosynthesis
  • sterol ester levels of are2 mutant strain is reduced to less than 26%
  • are1 are2 double mutant strain is almost totally deficient in sterol esterification
  • are1 are2 double mutant strain is reduced in sterol biosynthesis (half to one-third)
  • are1 are2 double mutant show normal growth
  • homozygous diploid are2 null mutants have significant reduced sporulation efficiency
  • part of the homozygous diploid sta1 null mutants arrest after first meiotic division
  • human ACAT
  • Exhibits sensitivity at 5 generations when grown in 10 uM nystatin. | Evi | PUBMED
  • Exhibits sensitivity at 5 generations when grown in synthetic complete - thr medium. | Evi | PUBMED
  • Exhibits sensitivity at 5 generations when grown in synthetic complete medium. | Evi | PUBMED
___
  • Mating and sporulation defects
    ..Sporulation efficiency | 112 Entries
Suppression:
  • human ACAT expressed in sat1 are1 (sat2) mutants catalyze esterification of cholesterol
Click for larger Map
Physical Features
Coordinates:665341 - 667269 (W)
Length:1929 nt
Contig:chrXIV
Exon Coordinates:665341 - 667269
GC Content:40.8 %
Protein Length:642 aa
Isoelectric Point:7.59
Molecular Weight:74023.3 Da
Transmembrane Domains:Begin - End / Length (aa)
217 - 239 / 23
254 - 276 / 23
289 - 311 / 23
326 - 348 / 23
407 - 424 / 18
439 - 461 / 23
482 - 504 / 23
565 - 587 / 23
619 - 641 / 23
9 TM- Domains
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: U51790
EMBL: U55383
EMBL: Z71634
PIR: S63350
UniProtKB: P53629
NCBI: NP_014416
Additional Links:
LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
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