| Entry: | YNL259c |
| Alias: | N0840 |
| Classification: | known protein | 5422 Entries | Evi
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PUBMED
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| Feature Type: | CDS |
| Features |
 |
Blast-Simap
DNA VIEW
PROTEIN VIEW
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| Similarity: |
similarity to members of the bacterial MerP family which code for periplasmic mercury transport proteinssimilarity to Staphylococcus aureus CadA cadmium efflux proteinsimilarity to Enterococcus hirae CopA copper transporterhomologs exist in Arabidopsis and C. elegans |
| Functional Classification: | - INTERACTION WITH THE ENVIRONMENT
..homeostasis
....homeostasis of cations
......homeostasis of metal ions (Na, K, Ca etc.)
| 98 Entries | Evi
- CELL RESCUE, DEFENSE AND VIRULENCE
..stress response
....oxidative stress response
| 55 Entries | Evi
|
PUBMED
- CELL RESCUE, DEFENSE AND VIRULENCE
..detoxification
| 117 Entries | Evi
- PROTEIN FATE (folding, modification, destination)
..protein folding and stabilization
| 93 Entries | Evi
|
PUBMED
- CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
..transported compounds (substrates)
....ion transport
......cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.)
........heavy metal ion transport (Cu+, Fe3+, etc.)
..........siderophore-iron transport
| 12 Entries | Evi
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PUBMED
|
|
InterPro:
| |
| Localization: | ATX1 localization details |
| Remarks: | synthesis is strongly induced by oxygen contains MTCXXC motif that is required for metal binding in bacterial proteins and in Menkes amd Wilsons copper homeostasis proteins of humans |
| Phenotypes: | Disruption: ATX1 details___
null mutants are deficient in the production of copper-Fet3pnull mutant is sensitive to paraquat, a generator of superoxide anionmutant has increased sensitivity to hydrogen peroxidenull mutant has no affect on aerobic growthnull mutant retards aerobic but not anaerobic growth of sod1 sod2 double null mutantnull mutants are iron-deficient and are defective in the high affinity uptake of ironExhibits sensitivity at 15 generations when grown in galactose. | Evi
|
PUBMED
___
Stress response defects
..Oxidizing agents
....H2O2
......H2O2 sensitivity | 18 Entries Stress response defects
..Oxidizing agents
....Paraquat
......Paraquat sensitivity | 1 Entry |
| Overexpression: | rescues sod1 null mutationmulticopy suppressor of oxygen toxicity in sod1 sod2 double null mutant through a copper-dependent mechanismoverproducing cells have higher copper levels, and lower expression of Cup1p |
| Suppression: | suppressor of amino acid auxotrophies of sod1 sod2 double null mutantrestores growth defect of sod1 mutant in oxygen and partially rescues paraquat toxicity of sod1 mutationsreverses lysine and methionine auxotrophy phenotype of sod1 mutations |
