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Chromosome
(chrI - chrXVI,chrMito,2-micron)

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  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
CNM67 Protein involved in cytokinesis 
Entry:YNL225c
Alias:CNM1; N1264
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (17.7 %) ;  |  Homologs in   Hemiascomycota (87.8 %);  Basidiomycota (15.1 %);  Fungi (87.8 %);  Eukaryota (87.8 %);  Plants (20.3 %);  Mammalia (17.4 %);  Human (16.3 %);  Bacteria (17.5 %);  All except yeast (87.8 %)
  • similarity to Giardia lamblia median body protein
Functional Classification:
  • CELL TYPE DIFFERENTIATION
    ..fungal/microorganismic cell type differentiation
    ....fungal and other eukaryotic cell type differentiation
    ......development of asco- basidio- or zygospore | 167 Entries | Evi
  • BIOGENESIS OF CELLULAR COMPONENTS
    ..cytoskeleton/structural proteins
    ....microtubule cytoskeleton | 47 Entries | Evi | PUBMED
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....mitotic cell cycle and cell cycle control | 447 Entries | Evi
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....cytokinesis (cell division) /septum formation and hydrolysis | 71 Entries | Evi
Localization:  CNM67 localization details
  • cytoskeleton
    ..spindle pole body
Remarks:
  • chaotic nuclear migration
Phenotypes:  Disruption: CNM67 details
  • viable
___
  • cnm67 deletion mutant shows slow growth phenotype | PUBMED
  • mutants show severe spindle misorientation and nuclear migration defect | PUBMED
  • mutants are frequently multinucleate or anucleate | PUBMED
  • mutants are multibudded and show a reduced ability to undergo cytokinesis | PUBMED
  • mutants show impaired morphogenesis | PUBMED
  • cnm67Delta1 cells that lack a detectable outer plaque of the spindle pole body still have cytoplasmic microtubules that are essential for spindle orientation and nuclear migration | PUBMED
  • mutants show no increased benomyl sensitivity compared to wildtype cells | PUBMED
___
  • Mating and sporulation defects
    ..Sporulation efficiency | 112 Entries
  • Cell morphology and organelle mutants
    ..Budding mutants
    ....Multibudded cells | 16 Entries
Click for larger Map
Physical Features
Coordinates:224470 - 222725 (C)
Length:1746 nt
Contig:chrXIV
Exon Coordinates:224470 - 222725
GC Content:35 %
Protein Length:581 aa
Isoelectric Point:5.74
Molecular Weight:67400.6 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: Z71501
EMBL: Z69381
PIR: S63183
UniProtKB: P53865
NCBI: NP_014174
Additional Links:
CYGD Pathways:
  • Components of the spindle pole and the spindle pole
    • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
    • To submit new information about this entry, please write to

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