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(chrI - chrXVI,chrMito,2-micron)

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About CYGD


MIPS Fungal Genomes

mips home MIPS-FUNGI-ADM      FTP
SSU72 Suppressor of cs mutant of sua7 
Entry:YNL222w
Alias:N1279
Classification:known protein | 5422 Entries
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW

Similarity:
Paralogs (10.8 %) ;  |  Homologs in   Hemiascomycota (99 %);  Basidiomycota (51.4 %);  Fungi (99 %);  Eukaryota (99 %);  Plants (42.7 %);  Mammalia (43.2 %);  Human (42.2 %);  Bacteria (19.5 %);  All except yeast (99 %)

  • strong similarity to C.elegans hypothetical protein
  • has similarity to ATP-dependent RNA helicases but it unlikely to have this function
Functional Classification:
  • CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM
    ..cellular signalling
    ....enzyme mediated signal transduction
    ......protein kinase | 57 Entries | Evi | PUBMED
  • TRANSCRIPTION
    ..RNA synthesis
    ....mRNA synthesis
    ......transcriptional control | 495 Entries | Evi
  • PROTEIN FATE (folding, modification, destination)
    ..protein modification
    ....modification by phosphorylation, dephosphorylation, autophosphorylation | 186 Entries | Evi | PUBMED
  • REGULATION OF METABOLISM AND PROTEIN FUNCTION
    ..regulation of protein activity
    ....enzymatic activity regulation / enzyme regulator | 180 Entries | Evi | PUBMED
  • REGULATION OF METABOLISM AND PROTEIN FUNCTION
    ..regulation by
    ....regulation by modification | 15 Entries | Evi | PUBMED
  • TRANSCRIPTION
    ..RNA synthesis
    ....mRNA synthesis
    ......general transcription activities
    ........transcription termination | 14 Entries | Evi | PUBMED
  • TRANSCRIPTION
    ..RNA synthesis
    ....mRNA synthesis
    ......general transcription activities
    ........transcription initiation | 46 Entries | Evi | PUBMED
EC Number:
  • 3.1.3.16: Hydrolases
    ..Acting on Ester Bonds
    ....Phosphoric Monoester Hydrolases
    ......phosphoprotein phosphatase | 25 Entries | Evi | PUBMED
  • 3.1.3.48: Hydrolases
    ..Acting on Ester Bonds
    ....Phosphoric Monoester Hydrolases
    ......protein-tyrosine-phosphatase | 14 Entries | Evi | PUBMED
InterPro:
Localization:  SSU72 localization details
  • cytoplasm
  • nucleus
 TargetP: Mitochondrion  (RC = 5)
Remarks:
    • N-terminus is essential for function
    • cysteins are critical for function
    • has putative N-terminal zinc binding site
    • contains C-X2-C-X(6-25)-C-X2-C motif found in other transcription factors
    • has a potential nuclear localization sequence
Phenotypes:  Disruption: SSU72 details
  • lethal
___
  • ssu72-1 mutation affects transcription start site selection defective in transcriptional start site selection
  • mutant affects start site selection in vivo in a manner dependent upon Sua7p
___
  • Nucleic acid metabolism defects
    ..Transcriptional mutants
    ....other transcriptional mutants | 51 Entries
Click for larger Map
Physical Features
Coordinates:229095 - 229715 (W)
Length:621 nt
Contig:chrXIV
Exon Coordinates:229095 - 229715
GC Content:35.7 %
Protein Length:206 aa
Isoelectric Point:5.15
Molecular Weight:23469.5 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: Z71498
EMBL: U20390
PIR: S63180
UniProtKB: P53538
NCBI: NP_014177
Additional Links:
LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer

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