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| Search ORF/Gene/Description |
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Chromosome
(chrI - chrXVI,chrMito,2-micron) |
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| Entry: | YNL079c | | Alias: | N2332 | | Classification: | known protein | 5422 Entries | Evi
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PUBMED
| | Feature Type: | CDS | | Features |  |
Blast-Simap
DNA VIEW
PROTEIN VIEW
| | Similarity: |
strong similarity to Tpm2p and S.pombe cdc820% identical to vertebrate tropomyosins | | Functional Classification: | - CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
..transport routes
....vacuolar/lysosomal transport
| 154 Entries | Evi
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PUBMED
- CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
..transport routes
....cellular export and secretion
......vesicular cellular export
........exocytosis
| 33 Entries | Evi
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PUBMED
- CELL TYPE DIFFERENTIATION
..fungal/microorganismic cell type differentiation
....fungal and other eukaryotic cell type differentiation
......budding, cell polarity and filament formation
| 313 Entries | Evi
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PUBMED
- INTERACTION WITH THE ENVIRONMENT
..cellular sensing and response to external stimulus
....chemoperception and response
......pheromone response, mating-type determination, sex-specific proteins
| 189 Entries | Evi
- BIOGENESIS OF CELLULAR COMPONENTS
..cytoskeleton/structural proteins
....actin cytoskeleton
| 96 Entries | Evi
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PUBMED
- PROTEIN WITH BINDING FUNCTION OR COFACTOR REQUIREMENT (structural or catalytic)
..protein binding
| 392 Entries | Evi
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PUBMED
- CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
..transported compounds (substrates)
....RNA transport
| 86 Entries | Evi
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PUBMED
| | Localization: | TPM1 localization detailscytoplasmcytoskeletoncytoskeleton
..actin cytoskeletonnucleus | | Remarks: | abundant enough to bind all F-actin in the cellactin cables are required for cell cycle linked mitochondrial movements leading to inheritance |
PUBMED
| | Phenotypes: | Disruption: TPM1 details___
tpm1 mutant loses actin cables |
PUBMED
tpm mutant has reduced growth rate |
PUBMED
null mutants are heterogeneous in sizenull mutants have defects in polarity including delocalized chitin depositionnull mutants mate poorly due to defects in formation of mating projection and cell fusionmutants accumulate secretory vesiclesmutant phenotype is similar to myo2 phenotypemutant has delocalized actin patches, but can still carry out endocytosismutant shows wild type movement of cortical actin patchesCDC39, STE12, TEC1, WHI3, NAB1, DBR1, CDC55, SRV2 TPM1, SPA2, BIN1, DFG5, DFG9, DFG10, BUD8 and DFG16 mutations block filamentous growthtpm1, spa2, bin1, srv2, dfg5, dfg9 and dfg10 are defective in cell polarity switch but still invade agartpm1 disruption mutant shows abnormal mitochondrial distribution and morphology |
PUBMED
tpm1 disruption do not affect mitochondrial motor acticity in vitro |
PUBMED
___
Conditional phenotypes
..Slow-growth (slg) | 237 Entries Mating and sporulation defects
..Mating efficiency | 31 Entries Cell morphology and organelle mutants
..Budding mutants
....Bud localization | 35 Entries Cell morphology and organelle mutants
..Budding mutants
....Pseudohyphae formation | 31 Entries Cell morphology and organelle mutants
..Cytoskeleton mutants
....Actin cytoskeleton mutants | 48 Entries Cell morphology and organelle mutants
..Secretory mutants | 61 Entries Cell morphology and organelle mutants
..Mitochondrial mutants | 37 Entries Cell morphology and organelle mutants
..other cell morphology mutants | 57 Entries | | Overexpression: | rescues mdm20 null mutationoverexpression restores actin cables to act1-2 mutant |
PUBMED
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