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Chromosome
(chrI - chrXVI,chrMito,2-micron)

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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
DDR48 Heat shock protein 
Entry:YMR173w
Alias:FSP; YM8010.03
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (15.8 %) ;  |  Homologs in   Hemiascomycota (82.9 %);  Basidiomycota (14.2 %);  Fungi (82.9 %);  Eukaryota (82.9 %);  Plants (0 %);  Mammalia (2.1 %);  Human (0 %);  Bacteria (17.6 %);  All except yeast (82.9 %)
  • similarity to Erwinia ice nucleation protein and human RNA-binding protein FUS
Functional Classification:
  • CELL CYCLE AND DNA PROCESSING
    ..DNA processing
    ....DNA recombination and DNA repair
    ......DNA repair | 159 Entries | Evi | PUBMED
  • PROTEIN WITH BINDING FUNCTION OR COFACTOR REQUIREMENT (structural or catalytic)
    ..nucleotide/nucleoside/nucleobase binding
    ....ATP binding | 191 Entries | Evi | PUBMED
Localization:  DDR48 localization details
  • cytoplasm
Remarks:
  • stress protein induced by heat shock, DNA damage or osmotic stress
  • induced by nitroquinoline oxide(NQO)
  • induced by heat shock through the thermal stress element (TSE) in absence of Hsf1p
  • expression is higher in sfl1 null mutant than in SFL1 strain
  • induction by DNA damage requires ESR1, SPK1, and RAD17
  • has 8 repeats of SNNXDSYG
Phenotypes:  Disruption: DDR48 details
  • viable
___
  • spontaneous mutation rate in null mutants is 6-14 fold higher, by his3 reversion
  • null mutant has slightly higher sensitivity to 4-nitroquinoline-1-oxide and heat shock
  • null mutant is less flocculent
  • mutants have defects in DNA metabolism
___
  • Cell morphology and organelle mutants
    ..Flocculence | 14 Entries
  • Stress response defects
    ..Heat shock sensitivity | 14 Entries
  • Sensitivity to aminoacid analogs and other drugs
    ..other aminoacid analogs and other drugs | 51 Entries
Click for larger Map
Physical Features
Coordinates:608688 - 609980 (W)
Length:1293 nt
Contig:chrXIII
Exon Coordinates:608688 - 609980
GC Content:39.2 %
Protein Length:430 aa
Isoelectric Point:4.22
Molecular Weight:46232.8 Da
Mature Protein:2-430
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: Z49808
EMBL: M36110
PIR: S55120
NCBI: NP_013897
Additional Links:
LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
    • To submit new information about this entry, please write to

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