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(chrI - chrXVI,chrMito,2-micron)

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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
SEC14 Phosphatidylinositol(PI)/phosphatidylcholine(PC) transfer protein 
Entry:YMR079w
Alias:PIT1; YM9582.04
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (61.3 %) ;  |  Homologs in   Hemiascomycota (86.2 %);  Basidiomycota (50 %);  Fungi (86.2 %);  Eukaryota (86.2 %);  Plants (29.9 %);  Mammalia (21.2 %);  Human (24.4 %);  Bacteria (16.5 %);  All except yeast (86.2 %)
  • strong similarity to Sec14 proteins of other yeasts and YKL091c
  • homologous to a human protein that has a Sec14p-like domain and a protein-tyrosine-phosphatase domain
  • similarity to soybean Ssh1p and Ssh2p | PUBMED
  • A.thalliana homolog shows 22.5% overall sequence identity | PUBMED
Functional Classification:
  • CELL TYPE DIFFERENTIATION
    ..fungal/microorganismic cell type differentiation
    ....fungal and other eukaryotic cell type differentiation
    ......development of asco- basidio- or zygospore | 167 Entries | Evi | PUBMED
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transport routes
    ....vesicular transport (Golgi network, etc.) | 200 Entries | Evi | PUBMED
  • CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
    ..transported compounds (substrates)
    ....lipid/fatty acid transport | 44 Entries | Evi | PUBMED
InterPro:
Localization:  SEC14 localization details
  • cytoplasm
  • ER
  • golgi
    ..golgi membrane
  • nucleus
Remarks:
  • flux through CDP choline pathway may be critical to Golgi function
  • has PI/PC exchange activity
Phenotypes:  Disruption: SEC14 details
  • lethal
___
  • mutants accumulate Golgi and 80-100 nm vesicles
  • mutant is almost totally blocked for the endocytic uptake of lipid
  • mutants accumulate phosphatidylcholine (PC) in the Golgi
  • sec14-ts cki1 double mutant do not show INO1 repression by inositol and choline in the medium at the restrictive temperature | PUBMED
  • sec14-ts cki1, sec14-ts cct1 or sec14-ts cpt1 double mutants show stronger choline excretion phenotypes than single CDP-choline pathway mutants by increased turnover of phosphatidylcholine | PUBMED
___
  • Cell morphology and organelle mutants
    ..Secretory mutants | 61 Entries
Overexpression:
  • overproduction represses the CDP-choline pathway
Suppression:
  • one suppressor of sec14 mutants is the null mutant of choline kinase, CKI
  • null mutants can be bypass suppressed by cki, cct, cpt, bsr3, sac1, bsd1, and bsd2 mutations
Click for larger Map
Physical Features
Coordinates:424988 - 426058 (W)
Length:1071 nt
Contig:chrXIII
Exon Coordinates:424988 - 424996 | Evi | PUBMED
425153 - 426058 | Evi | PUBMED
GC Content:39 %
Protein Length:304 aa
Isoelectric Point:5.37
Molecular Weight:34900.9 Da
Mature Protein:2-304
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: X15483
EMBL: Z49259
PIR: A30106
NCBI: NP_013796
Additional Links:
CYGD Tables:
  • The Yeast homologues of human disease-associated genes
    • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
    • To submit new information about this entry, please write to

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