GSFLogo GSF

 

 mipsLogo mips
GenRE

Navigation: » CYGD » Gene Report

Search ORF/Gene/Description

Chromosome
(chrI - chrXVI,chrMito,2-micron)

Catalogs:
Chromosome View
  I  II  III  IV  V  VI  VII
  VIII  IX  X  XI  XII  XIII
  XIV  XV  XVI  Mito
Other

Search / View

   Advanced Search

   Index Search

MPact protein interaction

Tables, Lists and Reviews

WUBLAST DNA/Protein

About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
MDM1 Intermediate filament protein 
Entry:YML104c
Alias:YM8339.15
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (15.6 %) ;  |  Homologs in   Hemiascomycota (89 %);  Basidiomycota (24.7 %);  Fungi (89 %);  Eukaryota (89 %);  Plants (13.9 %);  Mammalia (14 %);  Human (14.2 %);  Bacteria (16.9 %);  All except yeast (89 %)
  • similarity to mammalian vimentin and mouse epidermal keratin
Functional Classification:
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....mitotic cell cycle and cell cycle control | 447 Entries | Evi
  • CELL CYCLE AND DNA PROCESSING
    ..cell cycle
    ....nuclear and chromosomal cycle
    ......nuclear migration | 15 Entries | Evi | PUBMED
TC Class:
  • Non Transporting Mebrane Proteins
    ..Trafficking
    ....MITO
    ......The Mitochondrial Morphology Subfamily | 2 Entries | Evi | PUBMED
InterPro:
Localization:  MDM1 localization details
  • cytoskeleton
  • ambiguous
 TargetP: Secretory pathway  (RC = 1)
Remarks:
  • cell-cycle specific with execution point in late G1 or early S
    Phenotypes:  Disruption: MDM1 details
    • lethal
    • viable
    ___
    • mutants have retarded nuclear division and problems in transfer of nucleus to bud
    • mutants have temperature-sensitive growth and abnormal mitochondrial distribution at the non-permissive temperature
    • mdm1 class I mutants show defects in both mitochondrial and nuclear transmission | PUBMED
    • mdm1 class II mutants display defective mitochondrial inheritance but have no effect on nuclear movement | PUBMED
    • mdm1 class III mutants show abberrant nuclear inheritance but normal mitopchondrial distribution | PUBMED
    • mdm1 class I and II mutants als exhibit altered mitochondrial morphology, possessing primarily small, round mitochondria instead of the extended tubular structures found in wt cells | PUBMED
    • mdm1 class Ia and IIIa mutants are deficient for nuclear movement into daughter buds, while class Ib and IIIb mutants display a complete transfer of all nuclear DNA into buds | PUBMED
    • the mutations difining all three allelic classes map to 2 distinct domains within the protein | PUBMED
    • in the absence of this protein the reticulated mitochondria would lose their connections to the cytoskeleton and collapse into a basic spherical structure
    ___
    • Conditional phenotypes
      ..Heat-sensitivity (ts) | 313 Entries
    • Cell morphology and organelle mutants
      ..Mitochondrial mutants | 37 Entries
    Click for larger Map
    Physical Features
    Coordinates:62322 - 58939 (C)
    Length:3384 nt
    Contig:chrXIII
    Exon Coordinates:62322 - 58939
    GC Content:35.1 %
    Protein Length:1127 aa
    Isoelectric Point:6.01
    Molecular Weight:129982 Da
    Transmembrane Domains:Begin - End / Length (aa)
    9 - 43 / 35
    1 TM- Domain
    Retrieve Sequence: DNA /Protein
    Literature | References
    CYGD curated Lit.:PubMed
    PubMed:Search abstracts
    PubMed Central:Search full-text articles
    Sequence References:
    EMBL: X80835
    EMBL: Z49210
    PIR: S47445
    UniProtKB: Q01846
    NCBI: NP_013603
    Additional Links:
    CYGD Tables:
  • Putative targets of the GCN4 transcription factor
    • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
    • To submit new information about this entry, please write to

    © 2003 GSF - Forschungszentrum für Umwelt und Gesundheit, GmbH Ingolstädter Landstraße 1, D-85764 Neuherberg

    Imprint

    Disclaimer:
    MIPS Databases and associated information are protected by copyright. This server and its associated data and services are for academic, non-commercial use only. The GSF has no liability for the use of results, data or information which have been provided through this server. Neither the use for commercial purposes, nor the redistribution of MIPS database files to third parties nor the distribution of parts of files or derivative products to any third parties is permitted. Commercial users may contact the distributor Biomax Informatics AG.