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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
TSL1 Alpha,alpha-trehalose-phosphate synthase, 123 KD subunit 
Entry:YML100w
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (53.7 %) ;  |  Homologs in   Hemiascomycota (97.1 %);  Basidiomycota (25.6 %);  Fungi (97.1 %);  Eukaryota (97.1 %);  Plants (21.7 %);  Mammalia (9.6 %);  Human (9.1 %);  Bacteria (18.9 %);  All except yeast (97.1 %)
  • strong similarity to Tps3p, similarity to Tps1p Tps2p
Functional Classification:
  • METABOLISM
    ..C-compound and carbohydrate metabolism
    ....sugar, glucoside, polyol and carboxylate metabolism
    ......sugar, glucoside, polyol and carboxylate anabolism | 35 Entries | Evi | PUBMED
  • ENERGY
    ..metabolism of energy reserves (e.g. glycogen, trehalose) | 56 Entries | Evi
  • REGULATION OF METABOLISM AND PROTEIN FUNCTION
    ..regulation of protein activity
    ....enzymatic activity regulation / enzyme regulator | 180 Entries | Evi | PUBMED
EC Number:
  • 2.4.1.15: Transferases
    ..Glycosyltransferases
    ....Hexosyltransferases
    ......?,?-trehalose-phosphate synthase (UDP-forming) | 3 Entries
Pathway:
  • UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate
InterPro:
Localization:  TSL1 localization details
  • cytoplasm
 TargetP: Secretory pathway  (RC = 4)
Remarks:
  • repressed by glucose
  • C-terminal 700 aa are mainly in alpha-helices and beta-sheets
Phenotypes:  Disruption: TSL1 details
  • viable
___
  • TSL1 null mutation shows no obvious phenotype, TSL1 TPS3 double mutants show reduced Tre6P synthase activity during heat shock | PUBMED
Click for larger Map
Physical Features
Coordinates:70624 - 73920 (W)
Length:3297 nt
Contig:chrXIII
Exon Coordinates:70624 - 73920
GC Content:43.7 %
Protein Length:1098 aa
Isoelectric Point:6.17
Molecular Weight:123018 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: X72788
EMBL: X80835
PIR: S36868
UniProtKB: P38427
NCBI: NP_013608
Additional Links:
CYGD Pathways:
  • Metabolic and genetic control of gene expression
    • LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
    • To submit new information about this entry, please write to

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