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| Search ORF/Gene/Description |
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Chromosome
(chrI - chrXVI,chrMito,2-micron) |
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| Entry: | YLR214w | | Alias: | L8167.2 | | Classification: | known protein | 5422 Entries | Evi
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PUBMED
| | Feature Type: | CDS | | Features |  |
Blast-Simap
DNA VIEW
PROTEIN VIEW
| | Similarity: |
similarity to YOR384w, Fre2p, YOR381w, YNR060w, YLL051c and YOL152wFre1p is a cytochrome b similar to that of NADPH oxidasesimilarity to large beta subunit of human NADPH oxidasehas some similarity to human cytochrome b558 | | Functional Classification: | - INTERACTION WITH THE ENVIRONMENT
..homeostasis
....homeostasis of cations
......homeostasis of metal ions (Na, K, Ca etc.)
| 98 Entries | Evi
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PUBMED
- CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
..transport routes
....cellular import
| 150 Entries | Evi
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PUBMED
- CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES
..transported compounds (substrates)
....ion transport
......cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.)
........heavy metal ion transport (Cu+, Fe3+, etc.)
| 53 Entries | Evi
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PUBMED
| | EC Number: | - 1.16.1.7: Oxidoreductases
..Oxidizing metal ions
....With NAD+ or NADP+ as acceptor
......ferric-chelate reductase
| 7 Entries | Evi
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PUBMED
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Cofactor: | | | TC Class: | - Non Transporting Mebrane Proteins
..Oxidoreductases
....Iron Reductases
......The Iron Reductase Type 1 Subfamily | 6 Entries |
Evi
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PUBMED
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InterPro:
| | | Localization: | FRE1 localization detailsplasma membranecytoplasmER TargetP: Secretory pathway
(RC = 1)
| | Remarks: | Fre1p and Fre2p are rate-limiting for growth on ferric ironinduction by iron deprivation contains a HPFTXXS motif which is believed to function in FAD bindingcontains a gly-rich motif and cys/gly couplet which seems to be involved in NADPH bindingcontains a bis-heme motif (his-294/his-308 and his-364/his-378) | | Phenotypes: | Disruption: FRE1 details___
mutant is sensitive to iron-deprivation and lacks uptake of ferric ironnull mutant is normal for uptake of ferrous ironpoint mutation in single his-294,his-308,his-364 and his-378 positions show very low heme binding and enzymatic activity |
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