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(chrI - chrXVI,chrMito,2-micron)

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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
MAS1 Mitochondrial processing peptidase 
Entry:YLR163c
Alias:L9632.10; MIF1; PEP
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Overlapping Feature:
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (27 %) ;  |  Homologs in   Hemiascomycota (94.4 %);  Basidiomycota (52.8 %);  Fungi (94.4 %);  Eukaryota (94.4 %);  Plants (40.9 %);  Mammalia (41.9 %);  Human (41.9 %);  Bacteria (35.7 %);  All except yeast (94.4 %)
  • strong similarity to other mitochondrial processing peptidases
  • 35% identical to Mas2
Functional Classification:
  • PROTEIN FATE (folding, modification, destination)
    ..protein modification
    ....protein processing (proteolytic) | 89 Entries | Evi | PUBMED
EC Number:
  • 3.4.24.64: Hydrolases
    ..Acting on peptide bonds (Peptidases)
    ....Metalloendopeptidases
    ......mitochondrial processing peptidase | 2 Entries | Evi | PUBMED
Cofactor:
  • divalent cations;manganese
InterPro:
Localization:  MAS1 localization details
  • mitochondria
 TargetP: Mitochondrion  (RC = 2)
 Mitop2:  Mitochondrial probability - 98  %
Remarks:
  • enhancing (beta) subunit
  • one of the few essential proteins of mitochondria
  • in vitro and in vivo, yeast beta-MPP can be substituted for by beta-MPP from rat or Neurospora | PUBMED
    Phenotypes:  Disruption: MAS1 details
    • lethal
    ___
    • null mutant continues to import proteins but eventually growth stops
    • depletion of Mas1p causes overproduction of Mas2p
    Overexpression:
    • when overproduced, precipitates in mitochondrial matrix
    Suppression:
    • overexpression of SMF1 or addition of 1 MM Mn2+ complements mas1 ts mutant
    Click for larger Map
    Physical Features
    Coordinates:493256 - 491868 (C)
    Length:1389 nt
    Contig:chrXII
    Exon Coordinates:493256 - 491868
    GC Content:39.6 %
    Protein Length:462 aa
    Isoelectric Point:6.54
    Molecular Weight:51084 Da
    Mature Protein:20-462
    Retrieve Sequence: DNA /Protein
    Literature | References
    CYGD curated Lit.:PubMed
    PubMed:Search abstracts
    PubMed Central:Search full-text articles
    Sequence References:
    EMBL: U51921
    PIR: S00552
    UniProtKB: P10507
    NCBI: NP_013264
    Additional Links:
    LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
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