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Chromosome
(chrI - chrXVI,chrMito,2-micron)

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About CYGD


MIPS Fungal Genomes
mips home MIPS-FUNGI-ADM      FTP
SPE4 Spermine synthase 
Entry:YLR146c
Alias:L3305; L9634.5
Classification:known protein | 5422 Entries | Evi | PUBMED
Feature Type:CDS
Features
   Blast-Simap    DNA VIEW    PROTEIN VIEW
Similarity:
Paralogs (49 %) ;  |  Homologs in   Hemiascomycota (91.7 %);  Basidiomycota (19.1 %);  Fungi (91.7 %);  Eukaryota (91.7 %);  Plants (41.9 %);  Mammalia (47.1 %);  Human (46.7 %);  Bacteria (39 %);  All except yeast (91.7 %)
  • strong similarity to Spe3p and other spermidine synthases | PUBMED
Functional Classification:
  • METABOLISM
    ..amino acid metabolism
    ....metabolism of urea cycle, creatine and polyamines
    ......metabolism of polyamines
    ........biosynthesis of polyamines | 3 Entries | Evi | PUBMED
  • METABOLISM
    ..metabolism of vitamins, cofactors, and prosthetic groups
    ....biosynthesis of vitamins, cofactors, and prosthetic groups | 110 Entries | Evi | PUBMED
  • METABOLISM
    ..secondary metabolism
    ....metabolism of secondary products derived from primary amino acids
    ......metabolism of amines | 4 Entries | Evi
EC Number:
  • 2.5.1.22: Transferases
    ..Transferring Alkyl or Aryl Groups, Other than Methyl Groups
    ....Transferring Alkyl or Aryl Groups, Other than Methyl Groups
    ......spermine synthase | 1 Entry | Evi | PUBMED
Pathway:
  • polyamine-biosynthetic pathway
InterPro:
Localization:  SPE4 localization details
  • cytoplasm
Remarks:
  • spermine is not essential for growth of S. cerevisiae | PUBMED
  • aa 95 to 100 are perfectly conserved among all eukaryotic spermidine synthases and yeast, human and mouse spermine synthases | PUBMED
  • contains S-adenosylmethionine binding motif (aa 96G, 98G,100G, 119D, 121D, 151D, 185L, 198L ) | PUBMED
Phenotypes:  Disruption: SPE4 details
  • viable
___
  • null mutant has neither spermine nor spermine synthase activity | PUBMED
  • null mutant shows increased spermidine synthase activity | PUBMED
  • null mutant contains the same low amount of decarboxylated S-adenosylmethionine as wild type cells | PUBMED
  • null mutant has normal morphology, sporulation and growth like wild type in the absence of exogenous polyamines | PUBMED
Click for larger Map
Physical Features
Coordinates:433726 - 432824 (C)
Length:903 nt
Contig:chrXII
Exon Coordinates:433726 - 432824
GC Content:38.9 %
Protein Length:300 aa
Isoelectric Point:5.02
Molecular Weight:34091 Da
Retrieve Sequence: DNA /Protein
Literature | References
CYGD curated Lit.:PubMed
PubMed:Search abstracts
PubMed Central:Search full-text articles
Sequence References:
EMBL: Z73318
EMBL: U53879
PIR: S64995
UniProtKB: Q12455
NCBI: NP_013247
Additional Links:
LinkOut:
  • SGD - Saccharomyces Genome Database
  • YGOB - Yeast Gene Order Browser
  • yMGV - yeast Microarray Global Viewer
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